64429-65-8Relevant academic research and scientific papers
Branched-chain sugars. XXXVI. A new synthesis of methyl 4-O-benzoyl-3-benzoylamino-2,3,6-trideoxy-3-C-methyl-α-L-xylo-hexopyranoside, a derivative of the branched-chain amino sugar of antibiotic A35512B
Yasumori,Sato,Hashimoto,Yoshimura
, p. 2538 - 2542 (2007/10/02)
The compound was synthesized from methyl 4-0-benzyl-2,6-dideoxy- beta -L-threo-hexopyranosid-3-ulose through cyanomesylation, reductive spiro aziridine formation, and reductive ring-opening. When (2-methyoxyethoxymethyl) group was used as the protecting g
7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
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, (2008/06/13)
A series of compounds showing high antileukemic activity against P388 murine leukemia and increased aqueous solubility due to substitution of --OH for the known --NH 2 at the 3'' position of the hexopyranose sugar, i.e., daunosamine.These compounds are coupled products of aglycon selected from daunomycinone, desmethoxy daunomycinone, adriamycinone and carminomycinone. These compounds are coupled at the 0-7 position of the aglycon with an α-L-lyxo hexopyranose sugar, which sugar isomer particularly sustains or potentiates the biological activity of the coupled compound as well as ameliorates the dose related cardiotoxicity of the parent and known compounds set out below: STR1
