64479-79-4Relevant academic research and scientific papers
Selective gelation of N-(4-pyridyl)nicotinamide by copper(II) salts
Ghosh, Dipankar,Lebedyte, Ieva,Yufit, Dmitry S.,Damodaran, Krishna K.,Steed, Jonathan W.
, p. 8130 - 8138 (2015)
We report the selective gelation properties of the copper(ii) complexes of N-(4-pyridyl)nicotinamide (4PNA). The morphology of the xerogels was examined by scanning electron microscopy (SEM). The correlation between the X-ray powder diffraction (XRPD) pattern of the xerogels and the single crystal structure of the copper(ii) acetate complex suggests that the single crystal X-ray data represent a good structural model for the gel fibers, and that gelation arises from the presence of a 1D hydrogen-bonded chain between gelator amide groups and coordinated anions, while the presence of strongly bound water in non-gelator systems results in the formation of more extensively hydrogen-bonded crystalline networks. The selective gelation of all the copper(ii) salts compared to the other metal salts may be attributed to the Jahn-Teller distorted nature of copper(ii), which weakens water binding in all copper(ii) salts.
Synthesis and characterization of one, two and three-dimensional Cu(I) polymers supported by bipyridylamide ligands
Mugenzi, Clement,Powell, Douglas R.,Gerasimchuk, Nikolay N.,Yang, Lei
, p. 39 - 46 (2018/08/09)
Reaction of bipyridylamide ligands N-(3-pyridyl)nicotinamide (3-pna), N-(4-pyridyl)nicotinamide (4-pna) and N-(4-pyridyl)isonicotinamide (4-pina) with Cu(I) salts afforded four coordination polymers. X-ray crystallography analysis showed one-, two- and three-dimensional networks. The correlation between the pyridyl nitrogen donor disposition and dimensionality of the structures was discussed. Reflectance UV–Vis and fluorescence spectroscopic methods were used to characterize the MLCT features of these complexes. Thermal stability of the coordination polymers under nitrogen was also investigated.
Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions
Vrijdag, Johannes L.,Delgado, Francisca,Alonso, Nerea,De Borggraeve, Wim M.,Prez-Macias, Natalia,Alczar, Jesus
supporting information, p. 15094 - 15097 (2014/12/11)
A fast and efficient protocol for the formation of amides from low nucleophilic amines and esters in flow is described. Products were obtained in good to excellent yields and with the advantage of simultaneous mixing of all reagents at once, avoiding steps for intermediate formation. The protocol is also suitable to be combined with ester synthesis, resulting in the preparation of amides in-line from haloarenes. This journal is
INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE
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Page/Page column 42, (2013/08/15)
Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors
Li, Rongshi,Martin, Mathew P.,Liu, Yan,Wang, Binglin,Patel, Ronil A.,Zhu, Jin-Yi,Sun, Nan,Pireddu, Roberta,Lawrence, Nicholas J.,Li, Jiannong,Haura, Eric B.,Sung, Shen-Shu,Guida, Wayne C.,Schonbrunn, Ernst,Sebti, Said M.
supporting information; experimental part, p. 2474 - 2478 (2012/05/20)
Using high concentration biochemical assays and fragment-based screening assisted by structure-guided design, we discovered a novel class of Rho-kinase inhibitors. Compound 18 was equipotent for ROCK1 (IC50 = 650 nM) and ROCK2 (IC50 = 670 nM), whereas compound 24 was more selective for ROCK2 (IC50 = 100 nM) over ROCK1 (IC50 = 1690 nM). The crystal structure of the compound 18-ROCK1 complex revealed that 18 is a type 1 inhibitor that binds the hinge region in the ATP binding site. Compounds 18 and 24 inhibited potently the phosphorylation of the ROCK substrate MLC2 in intact human breast cancer cells.
