64488-09-1

Upstream product

• 105-34-0 methyl 2-cyanoacetate 
• 95-00-1 2,4-dichloro-benzenemethanamine 

Downstream Products

• 1373889-70-3 C₁₉H₁₂Cl₃N₃O 
• 1373889-31-6 C₁₈H₁₄Cl₃N₃O 
• 1373889-67-8 C₁₈H₁₁Cl₂N₃O 
• 1373889-27-0 C₁₇H₁₃Cl₂N₃O 

Relevant academic research and scientific papers

Cyanoacetamides (IV): Versatile one-pot route to 2-quinoline-3-carboxamides

Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. Herein, we describe scope of a valuable general protocol for the synthesis of arrays of 2-aminoquinoline-3-carboxamides from cyanoacetamides and 2-aminobenzaldehydes or heterocyclic derivatives via a Friedlaender reaction variation. In many cases, the reactions involve a very convenient work up by simple precipitation and filtration. More than 40 new products are described. We foresee our protocol and the resulting derivatives becoming very valuable to greatly expanding the scaffold space of cyanoacetamide derivatives.

Derivatives of 3-carboxy pyrid-2-ones

Novel compounds belonging to the class of 1-substituted benzylpyrid-2-one-4,6-dialkyl and 4,5,6-trisubstituted-3-carboxylic acids, amides, esters and physiologically acceptable salts. These compounds possess biological activity and in particular are gametocides and plant growth regulators. Novel 1-substituted benzyl-3-cyano-4,5,6-trisubstituted pyrid-2-ones are also disclosed as intermediates.