(R)-(-)-Methyl glycidyl ether

Base Information

• Chemical Name: (R)-(-)-Methyl glycidyl ether
• CAS No.: 64491-70-9
• Molecular Formula: C4H8O2
• Molecular Weight: 88.1063
• Hs Code.: 29109000
• European Community (EC) Number: 626-218-1
• Nikkaji Number: J1.345.455H
• Mol file: 64491-70-9.mol

Synonyms:64491-70-9;(R)-(-)-Methyl glycidyl ether;(2R)-2-(methoxymethyl)oxirane;(R)-2-(Methoxymethyl)oxirane;(R)-Methyl glycidyl ether;(R)-Glycidyl Methyl Ether;(R)-(-)-Glycidyl methyl ether;(R)-(-)-methylglycidyl ether;Methyl[(S)-glycidyl] ether;(R)-2-Methoxymethyl-oxirane;LKMJVFRMDSNFRT-BYPYZUCNSA-N;(R)-1-Methoxy-2,3-epoxypropane;(2R)-2-[(methyloxy)methyl]oxirane;MFCD00273372;AKOS017343589;(R)-(-)-Glycidyl methyl ether, 97%;CS-0165613;G0280;D90741;EN300-123986;A834778

Chemical Property of (R)-(-)-Methyl glycidyl ether

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 21.6mmHg at 25°C
• Refractive Index: n20/D 1.406(lit.)
• Boiling Point: 116.5 °C at 760 mmHg
• Flash Point: 8.1 °C
• PSA: 21.76000
• Density: 0.998 g/cm³
• LogP: 0.03160
• Storage Temp.: Flammables area
• Water Solubility.: soluble
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 88.052429494
• Heavy Atom Count: 6
• Complexity: 44.8

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(Methoxymethyl)oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; Xi
• Hazard Codes: F,Xi
• Statements: 11-19-36/37/38
• Safety Statements: 16-26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COCC1CO1
• Isomeric SMILES: COC[C@H]1CO1

Technology Process of (R)-(-)-Methyl glycidyl ether

There total 4 articles about (R)-(-)-Methyl glycidyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + (S)-3-methoxy-1,2-propanediol (71484-94-1) + R(-)-glycidyl methyl ether (64491-70-9) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With water; (R,R)-[Co(salen)]2*GaCl₃; at 20 ℃; for 3h;

DOI:10.1016/j.jorganchem.2005.12.044

Reference yield: 44.0%

glycidyl methyl ether (930-37-0) → 1-chloro-3-methoxy-propan-(S)-2-ol (890051-50-0) + 1-chloro-3-methoxy-propan-(R)-2-ol + R(-)-glycidyl methyl ether (64491-70-9) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With hydrogenchloride; (R,R)-[Co(salen)]2*GaCl₃; In diethyl ether; at 0 - 4 ℃; for 2h;

DOI:10.1016/j.jorganchem.2005.12.044

Reference yield:

glycidyl methyl ether (930-37-0) → (R)-3-methoxy-1,2-propanediol (86195-49-5) + R(-)-glycidyl methyl ether (64491-70-9) + (2S)-2-(methoxymethyl)oxirane (64491-68-5)

Guidance literature:

With 4CF₃O₃S^(1-)*Co⁽³⁺⁾*Y⁽³⁺⁾*C₃₆H₅₂N₂O₂^(2-); water; In neat (no solvent); at 20 ℃; for 12h; Overall yield = 21 %; enantioselective reaction;

DOI:10.1039/c5ra12408e

upstream raw materials:

glycidyl methyl ether

Downstream raw materials:

(2R)-3-methoxy-1-(2-nitroimidazol-1-yl)-2-propanol

2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2-hydroxy-3-methoxy-propyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]benzamide

CE-224,535

(2R)-1-Methoxy-3-{4-[(10-{[2-methyl-2'-trifluoromethyl-[1,1'-biphenyl]-4-yl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl)carbonyl]piperazin-1-yl}propan-2-ol