91538-60-2

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 20939-77-9 2-acetamidobenzyl alcohol 
• 142598-80-9 acetic acid-[2-((E)-p-tolylimino-methyl)-anilide] 
• 55857-35-7 (E)-N-(2-aminobenzylidene)-4-methylaniline 
• 13493-47-5 N-(2-formylphenyl)acetamide 

Downstream Products

• 56008-61-8 2-amino-5-nitrobenzaldehyde 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 77242-30-9 (2-amino-5-nitrophenyl)methanol 
• 21872-92-4 6-amino-3-quinolinecarboxylic acid ethyl ester 
• 85870-50-4 6-amino-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid 
• 85870-49-1 1,2-dihydro-6-nitro-2-oxo-3-quinolinecarboxylic acid 
• 91538-58-8 2-chloro-6-nitro-3-quinolinecarboxylic acid ethyl ester 
• 85870-48-0 1,2-dihydro-6-nitro-2-oxo-3-quinolinecarboxylic acid ethyl ester 
• 1003024-71-2 methyl 3-(2-acetamido-5-nitrophenyl)-3-hydroxy-2-methylenepropanoate 
• 3558-18-7 5-nitro-N-acetylanthranilic acid 
• 861222-14-2 acetic acid-(2-hydroxymethyl-4-nitro-anilide) 
• 248937-21-5 (S,R)-2-[(2-hydroxy-1-phenylethyl)amino]-2-(2-iodo-5-nitrophenyl)ethanenitrile 
• 56008-60-7 2-iodo-5-nitrobenzaldehyde 
• 64495-55-2 6-nitroquinolin-2-ol 

Relevant academic research and scientific papers

NOVEL IMIDAZO-PYRAZINE DERIVATIVES

The invention provides novel imidazo-pyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, m, n, and R1to R3 are as described herein: formula (I). Further provided are pharmace

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedl?nder reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedl?nder condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.

A simple and efficient diastereoselective Strecker synthesis of optically pure α-arylglycines

A simple and economical method for the synthesis of highly functionalised α-amino nitriles, precursors to α-arylglycines with high optical purity is reported. For this purpose, (R) or (S)-2-amino-2- phenylethanol were used as chiral auxiliaries in a 1,3 Strecker reaction. Reactions were studied with a broad range of reagent systems for the generation of cyano nucleophile. Methodology has been extended for the synthesis of (S)-α-(2-iodo-5-nitrophenyl)glycine, (S)-α-(4- methoxyphenyl)glycine and (R)-β-(4-methoxyphenyl)alanine.

Identification of Quinoline Nitration Products by NOE

The structures of the products from the nitration of 2- and 4-oxodihydroquinolines were assigned based on Nuclear Overhauser Effects of their nmr spectra and confirmed by unambiguous synthesis.