2,3-DIFLUORO-4-BROMOBENZALDEHYDE

Base Information

• Chemical Name: 2,3-DIFLUORO-4-BROMOBENZALDEHYDE
• CAS No.: 644985-24-0
• Molecular Formula: C7H3BrF2O
• Molecular Weight: 221.001
• Hs Code.: 2913000090
• Mol file: 644985-24-0.mol

Synonyms:1-Bromo-2,3-difluoro-4-formylbenzene;2,3-Difluoro-4-bromobenzaldehyde;

Chemical Property of 2,3-DIFLUORO-4-BROMOBENZALDEHYDE

Chemical Property:

• Melting Point: 66-67℃
• Boiling Point: 239.859 °C at 760 mmHg
• Flash Point: 98.864 °C
• PSA: 17.07000
• Density: 1.758 g/cm³
• LogP: 2.53980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2,3-difluorobenzaldehyde 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2,3-difluorobenzaldehyde is used as pharmaceutical intermediates.

Technology Process of 2,3-DIFLUORO-4-BROMOBENZALDEHYDE

There total 5 articles about 2,3-DIFLUORO-4-BROMOBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,4-dibromo-2,3-difluoro-benzene (156682-52-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2,3-difluoro-benzaldehyde (644985-24-0)

Guidance literature:

1,4-dibromo-2,3-difluoro-benzene; With isopropylmagnesium chloride; lithium chloride; In tetrahydrofuran; at -35 - 40 ℃; for 2h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -30 - 15 ℃; for 3.5h;

Reference yield: 98.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2,3-difluoro-benzaldehyde (644985-24-0)

Guidance literature:

C₆H₂Br₃F; With isopropylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -35 - 40 ℃; for 2h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -30 - 15 ℃; for 3.5h;

Reference yield: 82.0%

1-bromo-2,3-difluorobenzene (38573-88-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2,3-difluoro-benzaldehyde (644985-24-0)

Guidance literature:

1-bromo-2,3-difluorobenzene; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 12h; Inert atmosphere;

upstream raw materials:

N,N-dimethyl-formamide

1,4-dibromo-2,3-difluoro-benzene

1-bromo-2,3-difluorobenzene

ortho-difluorobenzene

Downstream raw materials:

3-(4-bromo-2,3-difluoro-phenyl)-2,2-dimethyl-3-oxo-propionic acid methyl ester

[4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)-2,3-difluoro-phenyl]-carbamic acid benzyl ester

C₁₄H₆BrClFNO₂

5-(3-bromo-2-fluoro-6-formyl-phenoxy)-N,N'-di-tert-butyl-isophthalamide