64500-19-2Relevant academic research and scientific papers
Facile synthesis and antibacterial, antitubercular, and anticancer activities of novel 1,4-dihydropyridines
Sirisha, Kalam,Achaiah, Garlapati,Reddy, Vanga Malla
experimental part, p. 342 - 352 (2011/07/30)
A series of twenty new 4-substituted-2,6-dimethyl-3,5-bis-N-(heteroaryl)- carbamoyl-1,4-dihydropyridines have been prepared from a three-component one-pot condensation reaction of N-heteroaryl acetoacetamide, an aromatic/ heteroaromatic aldehyde, and ammonium acetate under four different experimental conditions. Except for the conventional method, all the experimental conditions were simple, eco-friendly, economical, and the reactions were rapid and high-yielding. The methods employed have been compared in terms of yields, cost, and simplicity. The synthesized compounds were characterized by different spectroscopic techniques and evaluated for their in-vitro anticancer, antibacterial, and antitubercular activities. Amongst the compounds tested, compound 25 exhibited the highest anticancer activity while compounds 14 and 18 exhibited significant antibacterial and antitubercular activities.
Microwave induced acetoacetylation of hetaryl and aryl amines
Suri,Satti,Suri
, p. 3709 - 3718 (2007/10/03)
Acetoacetylation of hetaryl and aryl amines by interaction with ethyl acetoacetate under microwave irradiation, without any catalyst and/or solvent, is reported.
