64526-34-7

Basic information

• Product Name: ara-tubercidin
• Synonyms: ara-tubercidin;4-Amino-7-(β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine;Ara Tb
• CAS NO: 64526-34-7
• Molecular Formula: C₁₁H₁₄N₄O₄
• Molecular Weight: 266.256
• Mol File: 64526-34-7.mol

Chemical Properties

• Boiling Point: 648.8°C at 760 mmHg
• Flash Point: 346.2°C
• Appearance: /
• Density: 1.9g/cm³
• Vapor Pressure: 1.02E-17mmHg at 25°C
• Refractive Index: 1.834
• PKA: 12.44±0.70(Predicted)
• CAS DataBase Reference: ara-tubercidin(CAS DataBase Reference)
• NIST Chemistry Reference: ara-tubercidin(64526-34-7)
• EPA Substance Registry System: ara-tubercidin(64526-34-7)

Safety Data

• Hazardous Substances Data: 64526-34-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8+,11?/m1/s1

Upstream product

• 21193-61-3 4-amino-5-bromo-7-(β-L-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 85335-76-8 7-[3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 

Downstream Products

• 28302-62-7 7-β-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5'-phosphate 

Relevant articles and documents

NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS

The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.

2' AND 3'-KETONUCLEOSIDES AND THEIR ARABINO AND XYLO REDUCTION PRODUCTS CONVENIENT ACCESS VIA SELECTIVE PROTECTION AND OXIDATION OF RIBONUCLEOSIDES

A number of 2',5'- or 3',5'-diprotected ribonucleosides and 5'-protected 2'- or 3'-deoxy-β-D-erythro-pentofuranosyl nucleosides have been oxidized to the corresponding 3' or 2'-ketonucleoside derivatives using chromium trioxide/pyridine/acetic anhydride or dimethyl sulfoxide/acetic anhydride.Reduction of the carbonyl functions with sodium borohydride gave the inverted arabino, xylo, or deoxy-threo isomers as predominant products by attack at the less hindered α-face of the sugar ring.Parallel reductions using sodium borodeuteride corroborated the epimeric ratios by demonstrating that complete oxidation of the original hydroxyl groups had occured.The deuterium labeling also aided in making NMR spectral assignments.