64528-59-2Relevant academic research and scientific papers
Resolution of chiral aliphatic and arylalkyl amines using immobilized Candida antarctica lipase and isolation of their R- and S-enantiomers
Davis,Durden
, p. 569 - 578 (2001)
The resolution of chiral aliphatic and arylalkyl amines in high enantiomeric excess (up to 97.5% ee for the R-enantiomers and up to 99.9% ee for the S-enantiomers) and good yield (50-80%) using immobilized Candida antarctica lipase and ethyl acetate as acyl donor has been demonstrated. A second resolution on the Ramine increased the enantiomeric excess to more than 99.5% (up to 99.9%).
The influence of conventional heating and microwave irradiation on the resolution of (RS)-sec-butylamine catalyzed by free or immobilized lipases
Pilissa?o, Cristiane,De Oliveira Carvalho, Patri?cia,Da Grac?a Nascimento, Maria
, p. 1688 - 1697 (2013/01/15)
The lipases CAL-B, PSL, PSL-C, PSL-D, and A. niger lipase, free or immobilized in starch (obtained from two types of yam, known in Brazil as cara? (Discorea alata L.) and inhame (Colocasia esculenta (L.) Schott) or gelatin films, were used in the acylation of (RS)-sec-butylamine with different acyl donors in various organic solvents applying conventional heating (CH) or microwave (MW) irradiation. In the case of free A. niger lipase, the conversion degrees were three times higher using MW irradiation when compared to conventional heating at 35 °C. Using free A. niger lipase, the (R)-amide was obtained with a conversion degree of 21percent, resulting in eep > 99percent and E-value (enantioselectivity value) > 200, in 1 min of reaction under MW irradiation. When the A. niger lipase was immobilized in yam starch films, the (R)-amide was obtained in moderate conversions of 8-25percent after 3 or 5 min of reaction under MW irradiation, but with higher selectivity (eep > 99percent and E > 200) in comparison with the free form (conversion degree of 45percent, eep 81percent and E value of 18).
