64528-63-8

Basic information

• Product Name: Propanamide, 2,2-dimethyl-N-(1-phenylethyl)-
• CAS NO: 64528-63-8
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Mol File: 64528-63-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Propanamide, 2,2-dimethyl-N-(1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2,2-dimethyl-N-(1-phenylethyl)-(64528-63-8)
• EPA Substance Registry System: Propanamide, 2,2-dimethyl-N-(1-phenylethyl)-(64528-63-8)

Safety Data

• Hazardous Substances Data: 64528-63-8(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 618-36-0 rac-methylbenzylamine 
• 1821-12-1 4-Phenylbutyric acid 
• 75-98-9 Trimethylacetic acid 
• 215657-43-5 N-pivaloyl-N-(2-fluorophenyl)methanesulfonamide 
• 300561-21-1 N-pivaloyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamide 
• 515863-57-7 N-(4,4-dimethyl-4,5-dihydro-thiazol-2-yl)-2,2,N-trimethyl-propionamide 
• 754-10-9 2,2-dimethylpropionamide 
• 100-41-4 ethylbenzene 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 
• 98-86-2 acetophenone 
• 1118-71-4 2,2,6,6-tetramethylheptane-3,5-dione 

Downstream Products

• 91797-84-1 (R)-(+)-N-(1-phenylethyl)-2,2-dimethylpropanamide 
• 64528-62-7 (1S)-(+)-N-(2,2-dimethylpropionyl)-1-phenylethylamine 
• 754-10-9 2,2-dimethylpropionamide 
• 64528-66-1 2,2-dimethyl-N-[1-phenylethyl]propanethioamide 

Relevant articles and documents

An Unconventional Reaction of 2,2-Diazido Acylacetates with Amines

We have discovered that 2,2-diazido acylacetates, a class of compounds with essentially unknown reactivity, can be coupled to amines through a new strategy that does not involve any reagents. 2,2-Diazido acetate is the unconventional leaving group under carbon–carbon bond cleavage. This reaction leads to the construction of amide bonds, tolerates various functionalities and is performed equally well in numerous solvents under experimentally simple conditions. We also demonstrate that the isolation of the 2,2-diazido acylacetate compounds can be circumvented: Acylacetates were easily fragmented when treated with (Bu4N)N3 and iodine in the presence of an amine at room temperature. By using this method, a broad range of acylacetates with various structural motifs were directly transformed into amides.

Copper-Catalyzed Reductive N-Alkylation of Amides with N-Tosylhydrazones Derived from Ketones

A CuI-catalyzed reductive coupling of ketone-derived N-tosylhydrazones with amides is presented. Under the optimized conditions, an array of N-tosylhydrazones derived from aryl–alkyl and diaryl ketones could couple effectively with a wide variety of (hete

NOVEL PYRIDINE OXIDE COMPOUND, AND PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE AND OPTICALLY ACTIVE CARBOXYLIC ACID DERIVATIVE WITH THE USE OF THE SAME

The invention relates to a pyridine oxide compound represented by formula (I), an optically active compound thereof, a salt thereof and a hydrate thereof, and, in the presence of the compound as a catalyst, performing 1) a method for producing an ester compound or an amide compound from a carboxylic acid equivalent and an alcohol or an amine, 2) an asymmetric esterification reaction or 3) an asymmetric amidation reaction. In formula (I), each R1 may be the same as the other R1 or different and each R1 represents an alkyl group, an aromatic group, a heterocyclic group, a carboxyl group, an ester group, a cyano group, a halogen atom, an oxygen atom, a sulfur atom or a nitrogen atom; each R2 may be the same as the other R2 or different and each R2 represents a hydrogen atom, an alkyl group, an aromatic group, a heterocyclic group, a carboxyl group, an ester group, a cyano group, a halogen atom, an oxygen atom or the like, and R3 and R4 may be the same or different and R3 and R4 each represent a hydrogen atom, an alkyl group, an aromatic group, a heterocyclic group, a carboxyl group, an ester group, a cyano group, a halogen atom, an oxygen atom or the like.