64532-94-1

Usage

Uses

Used in Plastic Industry:
Phosphoric acid, 2-(1-methylethyl)phenyl diphenyl ester is used as a plasticizer in polyvinyl chloride (PVC) for [application reason]. Its ability to increase the flexibility and workability of PVC makes it a valuable additive in the production of various plastic products.
Used in Flame Retardant Industry:
Phosphoric acid, 2-(1-methylethyl)phenyl diphenyl ester is used as a flame retardant for [application reason]. Its chemical structure allows it to slow down the combustion process, making it an effective component in flame-resistant materials.
Used in Pharmaceutical Research:
Phosphoric acid, 2-(1-methylethyl)phenyl diphenyl ester is used as a research compound for [application reason]. Studies have shown that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor, making it a potential candidate for further investigation in the development of pharmaceuticals targeting androgen-related conditions.

InChI:InChI=1/C27H25O4P/c1-21(2)24-17-9-10-18-25(24)26-19-11-12-20-27(26)31-32(28,29-22-13-5-3-6-14-22)30-23-15-7-4-8-16-23/h3-21H,1-2H3

Upstream product

• 88-69-7 2-(1-methylethyl)phenol 
• 2934-05-6 2,4-diisopropylphenol 
• 2078-54-8 2,6-diisopropylphenol 
• 2934-07-8 2,4,6-triisopropylphenol 
• 618-45-1 3-isopropylhydroxybenzene 
• 108-95-2 phenol 
• 2524-64-3 chlorophosphoric acid diphenyl ester 

Relevant academic research and scientific papers

Low Triphenylphosphate, High Phosphorous Content Isopropyl Phenyl Phosphates With High Ortho Alkylation

The present invention relates to low triphenyl phosphate, high phosphorous content aryl phosphates with high ortho alkylation that are suitable for use as flame retardant compositions, processes for their preparation, and their use as flame retardants.

Effects of triaryl phosphates on mouse and human nuclear receptors

The constitutively active receptor (CAR) is a crucial regulator of genes encoding for enzymes active in drug/steroid oxidation, conjugation, and transport. In our attempt to isolate the endogenous inhibitory ligand(s) for the mouse CAR, we found surprisingly that the inhibitory activity was associated with di- and tri-isopropylated phenyl phosphates that were present in livers of untreated mice. Trans-activation experiments in mammalian cells with synthetic compounds verified that mouse CAR was inhibited by various isopropylated phenyl phosphates (40-80%). Such triaryl phosphates are widely used as fire retardants, lubricants, and plasticizers, and some of them are known to disturb reproduction by currently unknown mechanisms. Equipped with the finding that these compounds could interact with mouse CAR, we proceeded to determine their functional effects on other nuclear receptors. Human CAR and pregnane X receptor (PXR) were variably activated (2-5-fold) by triaryl phosphates while mouse PXR, peroxisome proliferator-activated receptor-α, and vitamin D receptor were refractory. Among steroid hormone receptors, the human androgen receptor was inhibited by triphenyl phosphate and di-ortho-isopropylated phenyl phosphate (40-50%) and activated by di- and tri-para-substituted phenyl phosphates (2-fold). Our results add to the list of CAR and PXR activators and suggest steroid-dependent biological pathways that may contribute to the reproductive effects of triaryl phosphates.