645397-04-2

Upstream product

• 100-52-7 benzaldehyde 
• 645396-79-8 (3E,4aR,10aR)-3-benzylidene-4a-ethyl-7-hydroxy-3,4,4a,9,10,10a-hexahydro-1H-phenanthren-2-one 
• 107-21-1 ethylene glycol 

Downstream Products

• 645397-05-3 (3′E,4a′R,10a′R)-3′-benzylidene-4a′-ethyl-3′,4′,4a′,9′,10′,10a′-hexahydro-1′H-spiro[[1,3]dioxolane-2,2′-phenanthrene]-7′-yl 4-nitrobenzoate 

Relevant academic research and scientific papers

2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists

A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy to (R)-3-h

MODULATORS OF THE GLUCOCORTICOID RECEPTOR

The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1-R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment o