645414-75-1

Upstream product

• 78597-27-0 5⁽⁶⁾-iodobenzimidazole 
• 100-39-0 benzyl bromide 
• 21304-38-1 4-iodobenzene-1,2-diamine 
• 73183-34-3 bis(pinacol)diborane 
• 645414-74-0 1-benzyl-5-iodo-1H-benzoimidazole 

Downstream Products

• 645414-80-8 1,1',1''-tribenzyl-6-phenyl-1H,1'H,1''H-[2,5';2',5'']terbenzoimidazole 
• 645414-79-5 1,1'-dibenzyl-2'-iodo-6-phenyl-1H,1'H-[2,5']bibenzoimidazolyl 
• 645414-78-4 1,1'-dibenzyl-6-phenyl-1H,1'H-[2,5']bibenzoimidazolyl 

Relevant academic research and scientific papers

PROTEIN KINASE INHIBITORS

Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Synthesis of a terbenzimidazole topoisomerase I poison via iterative borinate ester couplings

A concise, efficient synthesis is described for a terbenzimidazole that acts as a potent topoisomerase I poison. The strategy involves iterative palladium-catalyzed borinate ester cross-couplings and should be applicable to the synthesis of analogs contai