64551-86-6

Upstream product

• 3480-59-9 N-(1-phenylethyl)benzamide 
• 2227-79-4 benzenecarbothioamide 
• 618-36-0 rac-methylbenzylamine 
• 24277-44-9 (1-isothiocyanato-ethyl)-benzene 
• 591-51-5 phenyllithium 
• 150-60-7 dibenzyl disulphide 

Downstream Products

• 89873-87-0 N-(1-Phenyl-ethyl)-N-thiobenzoyl-benzamide 
• 89873-89-2 N-(1-Phenyl-ethyl)-N-thiobenzoyl-acetamide 
• 89873-93-8 N-(1-Methyl-1,2-diphenyl-2-thioxo-ethyl)-benzamide 
• 89874-01-1 Thioacetic acid S-(1-acetyl-3-methyl-2,3-diphenyl-aziridin-2-yl) ester 
• 89873-97-2 2,3-Diphenyl-2-(acetylthio)-1-benzoyl-3-methylaziridine 

Relevant academic research and scientific papers

Iodine-Promoted Synthesis of Thioamides from 1,2-Dibenzylsulfane and Difurfuryl Disulfide

Thioamides can be generated at 100 °C in high yield through the reaction of 1,2-dibenzyldisulfane with difurfuryldisulfide using iodine as oxidant and DMSO as solvent. The protocol is metal- and additive-free, providing a convenient and economical way for the synthesis of various kinds of thioamides under mild conditions.

H-β-zeolite catalyzed transamidation of carboxamides, phthalimide, formamides and thioamides with amines under neat conditions

Efficient transamidation of unactivated carboxamides, phthalimides, formamides and thioamides with amines under solvent-free conditions using H-β-zeolite as a green and recyclable heterogeneous catalyst is described. Easy work up, high purity of the products, recyclability and environmentally-friendly nature of the catalyst are the attractive features of the present methodology. This is the first report for the transamidation of thioamides under heterogeneous conditions.

A Robust, Eco-Friendly Access to Secondary Thioamides through the Addition of Organolithium Reagents to Isothiocyanates in Cyclopentyl Methyl Ether (CPME)

The nucleophilic addition of widely available and variously functionalized organolithium reagents to isothiocyanates represents a straightforward, high-yielding, one-pot method to access secondary thioamides. The simple reaction conditions required and the broad scope (>50 cases examples) makes it a robust and reliable method to access both simple and complex thioamides, including enantiopure ones. Noxious and unpleasant-smelling sulfurating agents, usually employed in the literature established methods, are avoided during the whole synthetic procedure thus, rendering the protocol highly attractive, also for sustainability aspects.