64556-73-6Relevant academic research and scientific papers
A Solvent-Free Reaction for Silyl Enol Ethers Synthesis
Morozzi, Chiara,Rosati, Ornelio,Curini, Massimo,Lanari, Daniela
supporting information, p. 126 - 130 (2017/12/28)
Silyl enol ethers are extremely useful nucleophilic intermediates for chemical transformations because they are synthetically versatile substrates for a wide range of C-C bond-forming reactions. Here, we present a new, mild, and solvent-free procedure for the synthesis of silyl enol ethers that employs a catalytic amount of solid-supported base and an equimolar amount of N, O -(bistrimethylsilyl)acetamide as a silylating agent.
Syntheses of Vinyl Silane Phosphates: Novel Synthetic Intermediates
Koerwitz, Frederick L.,Hammond, Gerald B.,Wiemer, David F.
, p. 738 - 743 (2007/10/02)
A number of procedures have been developed for the synhesis of vinyl silane phosphates (VSP's), a new type of functional group bearing trialkylsilyl and diaryl (or dialkyl) phosphate groups on adjacent sp2 carbons. α-Silyl ketone enolates, acce
Reactions of Trialkylsilyl Trifluoromethanesulfonates, I. - Synthesis of Trialkylsilyl Enol Ethers
Emde, Herbert,Goetz, Andreas,Hofmann, Karin,Simchen, Gerhard
, p. 1643 - 1657 (2007/10/02)
The reactions of the ketones 2,2-bromoketones 6, α,β-unsaturated ketones 8, 1,2-diketones, and aliphatic aldehydes 20 with trialkylsilyl triflates 1 in the presence of triethylamine (4) at room temperature yield the silyl enol ethers 3, 7, 9, 11, and 21.The silylation of the unsymmetrical ketones 12 with 1a/4 runs regioselectively in the thermodynamical sense using 1a/12 in excess and yields the enol ethers 13t.The course of this reaction is discussed briefly.
