6456-01-5

Basic information

• Product Name: 1,3-Dimethyl-5,5-diphenylimidazolidine-2,4-dione
• Synonyms: 1,3-Dimethyl-5,5-diphenyl-2,4-imidazolidinedione;1,3-Dimethyl-5,5-diphenylhydantoin;1,3-Dimethyl-5,5-diphenylimidazolidine-2,4-dione;DMDPH
• CAS NO: 6456-01-5
• Molecular Formula: C₁₇H₁₆N₂O₂
• Molecular Weight: 280.32
• Mol File: 6456-01-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dimethyl-5,5-diphenylimidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethyl-5,5-diphenylimidazolidine-2,4-dione(6456-01-5)
• EPA Substance Registry System: 1,3-Dimethyl-5,5-diphenylimidazolidine-2,4-dione(6456-01-5)

Safety Data

• Hazardous Substances Data: 6456-01-5(Hazardous Substances Data)

Usage

General Description

Dimethyldiphenylhydantoin, also known as DMDPH, is a chemical compound with a molecular structure that includes two methyl groups (-CH3) attached to a diphenylhydantoin core. It has been employed as a reactant in the synthesis of other compounds and as a precursor in the production of various chemicals.

Upstream product

• 57-41-0 phenythoin 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 66242-64-6 1,3-dimethyl-4,5-diphenyl-4,5-dihydroxyimidazolidin-2-one 
• 1899-02-1 trimethylphenylammonium hydroxide 
• 96-31-1 N,N'-Dimethylurea 
• 134-81-6 benzil 
• 598-94-7 1,1-Dimethylurea 
• 76-93-7 Benzilic acid 

Downstream Products

• 4224-00-4 3-methyl-5,5-diphenyl-imidazolidine-2,4-dione 
• 21083-50-1 1,3-dimethyl-5,5-diphenyl-2-thioxo-imidazolidin-4-one 
• 16116-40-8 1,3-Dimethyl-5,5-diphenyl-dithiohydantoin 

Relevant articles and documents

Bioavailability and anticonvulsant activity of 2- cyanoguanidinophenytoin, a structural analogue of phenytoin

Phenytoin is extensively used in Europe and the United States for the treatment of generalized tonic clonic seizures (grand mal). However, the efficacy is lowered by the erratic bioavailability after oral administration. The current study was conducted in

Facile access to polymer supported zinc–salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium

The synthesis of polymer supported zinc–salen complex (PS-Zn–salen) is described. The mononuclear zinc(II)–salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectrophotometry (FT-IR), thermogravimetric analysis, scanning electron microscopy, surface area and pore size distribution by Brunauer–Emmett–Teller. The synthesized PS-Zn–salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, respectively. In spite of conventional heterogeneous catalysts, current PS-Zn–salen complex shows thermal stability up to 280?°C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn–salen is negligible, which was confirmed by AAS and hot filtration test.

4,5-dihydroxyimidazolidin-2-ones in an α-ureidoalkylation reaction of N-(carboxyalkyl)-, N-(hydroxyalkyl)-, and N-(aminoalkyl)ureas 3. * α-Ureidoalkylation of N-[2-(dimethylamino)ethyl]urea

α-Ureidoalkylation of N-[2-(dimethylamino)ethyl]urea with 1,3-unsubstituted, 1,3-dialkyl-, and 1,3-dimethyl-4,5-diphenyl-4,5- dihydroxyimidazolidin-2-ones(thiones) was systematically studied. Hitherto unknown N-[2-(dimethylamino)ethyl]glycolurils and their hydrochlorides were synthesized. The yields of the target glycoluril hydrochlorides decreased on going from 1,3-H2- to 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-ones and increased with the introduction of phenyl groups at the positions 4 and 5 of the starting 4,5-dihydroxyimidazolidin-2-one. X-ray diffraction study showed that 2-[2-(dimethylamino)ethyl]glycoluril crystallizes in the form of a conglomerate.