64586-20-5

Basic information

• Product Name: Benzene, 1-bromo-4-(1-isocyanato-1-methylethyl)-
• CAS NO: 64586-20-5
• Molecular Formula: C10H10BrNO
• Molecular Weight: 240.099
• Mol File: 64586-20-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-(1-isocyanato-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(1-isocyanato-1-methylethyl)-(64586-20-5)
• EPA Substance Registry System: Benzene, 1-bromo-4-(1-isocyanato-1-methylethyl)-(64586-20-5)

Safety Data

• Hazardous Substances Data: 64586-20-5(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 17797-12-5 1-(4-bromophenyl)-1-methylethylamine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1173047-86-3 2-(4-bromophenyl)propan-2-amine hydrochloride 
• 64586-24-9 N-(p-Brom-α,α-dimethylbenzyl)formamid 
• 2077-19-2 2-(4-bromophenyl)propan-2-ol 
• 32454-35-6 2-(4-bromophenyl)-2-methylpropionic acid 

Downstream Products

• 64797-98-4 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-propyl-urea 
• 64797-97-3 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-ethyl-urea 
• 64797-85-9 3-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-1,1-dipropyl-urea 
• 64797-81-5 3-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-1-ethyl-1-phenyl-urea 
• 64797-83-7 3-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-1,1-dimethyl-urea 
• 64797-99-5 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-butyl-urea 
• 64797-56-4 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-p-tolyl-urea 
• 64797-55-3 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-(3,5-dichloro-phenyl)-urea 
• 64797-79-1 3-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-1-methyl-1-phenyl-urea 
• 64797-88-2 1-Benzyl-3-[1-(4-bromo-phenyl)-1-methyl-ethyl]-1-methyl-urea 
• 64797-53-1 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-phenyl-urea 
• 64797-84-8 3-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-1,1-diethyl-urea 
• 64797-52-0 1-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-3-isopropyl-urea 
• 64797-80-4 3-[1-(4-Bromo-phenyl)-1-methyl-ethyl]-1-(3-chloro-phenyl)-1-methyl-urea 

Relevant articles and documents

TREATMENT OF CILIOPATHIES USING INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE (GCS)

This disclosure relates to a method of treating a ciliopathy in a subject, the method comprising administering to the subject an effective amount of a quinuclidine compound. Also disclosed is a pharmaceutical composition comprising a quinuclidine compound for use in said method.

A Copper-Catalyzed Aerobic [1,3]-Nitrogen Shift through Nitrogen-Radical 4-exo-trig Cyclization

A novel radical [1,3]-nitrogen shift catalyzed by copper diacetate under an oxygen atmosphere (1 atm) has been developed for the construction of a diverse range of indole derivatives from α,α-disubstituted benzylamine. In this reaction, oxygen was used as a clean terminal oxidant, and water was produced as the only by-product. Five inert bonds were cleaved, and two C?N bonds and one C?C double bond were constructed in one pot during this transformation. This unique method demonstrated broad application protential for the late-stage modification of biologically active natural products and drugs. Mechanistic investigations indicate that a unique 4-exo-trig cyclization of an aminyl radical onto a phenyl ring is involved in the catalytic cycle.