64589-06-6

Upstream product

• 599-67-7 1,1-diphenylethanol 
• 5558-66-7 2,2-diphenylpropanoic acid 
• 100-58-3 phenylmagnesium bromide 
• 862487-14-7 (1-isocyanatoethane-1,1-diyl)dibenzene 
• 22293-23-8 (1-azidoethane-1,1-diyl)dibenzene 
• 20912-56-5 1,1-diphenylethylamine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 249764-73-6 N-(1,1-diphenylethyl)-2-(trimethylsilyl)benzamide 
• 17876-72-1 2-(trimethylsilyl)benzamide 

Relevant academic research and scientific papers

Facile synthesis of sterically hindered and electron-deficient secondary amides from isocyanates

The big easy: The direct coupling of Grignard reagents to isocyanates provides a facile and robust solution for the synthesis of sterically hindered and electron-deficient secondary amides. The products are obtained in high yields without the need for excess reagents or chromatographic purification. Copyright

N-cumyl benzamide, sulfonamide, and aryl O-carbamate directed metalation groups. Mild hydrolytic lability for facile manipulation of directed ortho metalation derived aromatics

(Matrix Presented) N-Cumyl benzamide (2), sulfonamide (8), and O-carbamate (11) compounds undergo directed ortho metalation under standard conditions to give, after quench with a variety of electrophiles, the substituted products 3, 9, and 12, respectively. Regiospecific and convenient approaches to phthalimides (7), 1,2-benzisothiazole 1,1-dioxides (10b), and ortho-substituted phenols (13a) and salicylamides (13b) are thereby established The mild deprotection protocol for these new cumyl directed metalation groups (DMGs) suggests that they will supersede previous corresponding groups for synthetic anionic aromatic chemistry.