64603-67-4

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-6-(chloromethyl)-1,3-benzodioxole is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features, including the bromine and chloromethyl groups, make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
This chemical compound is also utilized in the production of agrochemicals, where it serves as a crucial intermediate in the synthesis of various agrochemical products. Its halogenated nature allows for the creation of compounds with specific pesticidal or herbicidal properties.
Used in Organic Synthesis:
5-Bromo-6-(chloromethyl)-1,3-benzodioxole is employed as a versatile building block in organic synthesis, enabling the creation of a wide range of organic compounds with diverse applications. Its reactivity and functional groups make it suitable for various chemical reactions, leading to the formation of new molecules with potential uses in various industries.
Used in Drug Discovery and Development:
Due to its structural features, 5-Bromo-6-(chloromethyl)-1,3-benzodioxole has potential applications in drug discovery and development. Researchers can use 5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE as a starting material to explore new chemical entities with potential therapeutic effects, contributing to the advancement of medicine and healthcare.
It is important to handle 5-Bromo-6-(chloromethyl)-1,3-benzodioxole with care, as it may pose health hazards and environmental risks. Proper safety measures and disposal methods should be followed to minimize any potential impact.

InChI:InChI=1/C8H6BrClO2/c9-6-2-8-7(11-4-12-8)1-5(6)3-10/h1-2H,3-4H2

Upstream product

• 6642-34-8 6-bromopiperonyl alcohol 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 274-09-9 Methylenedioxybenzene 
• 20850-43-5 5-(chloromethyl)-1,3-benzodioxole 
• 495-76-1 piperonol 

Downstream Products

• 5434-50-4 2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile 
• 112378-10-6 8-benzyloxy-N-benzoyl-1-(2'-bromo-4',5'-methylenedioxybenzyl)-1,2-dihydro-7-methoxyisoquinoline-1-carbonitrile 
• 86817-56-3 8-benzyloxy-1-(2'-bromo-4',5'-methylenedioxybenzyl)-7-methoxyisoquinoline 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 5470-14-4 (6-bromobenzo[1,3]dioxol-5-yl)acetic acid 
• 112378-15-1 8-benzyloxy-1-(2'-bromo-4',5'-methylenedioxybenzyl)-1,2,3,4-tetrahydro-7-methoxy-N-methylisoquinoline 
• 112378-13-9 8-benzyloxy-1-(2'-bromo-4',5'-methylenedioxybenzyl)-7-methoxy-N-methylisoquinolinium iodide 
• 94670-91-4 1-phenyl-2-(2'-bromo-4',5'-methylenedioxyphenyl)ethanone 
• 40360-71-2 anhydrolycorine-7-one 
• 52886-06-3 hippadine 
• 130-86-9 protopine 

Relevant academic research and scientific papers

2-Amino-purine derivative compound, preparing method and use thereof

According to one aspect, provided are a purine compound, a stereoisomer, a derivative, a solvate, or a pharmaceutically acceptable salt thereof, a manufacturing method thereof and uses thereof. According to the same, the compound, and the stereoisomer, derivative, solvate, or pharmaceutically acceptable salt thereof have low cytotoxicity, and exhibit high selective inhibitory activity against HSP90, and antiproliferative effect of cancer cells, thereby being useful for preventing or treating cancer.(AA) Density(BB) Compound(CC) andbeta;- tubulinCOPYRIGHT KIPO 2018

Novel pyrrolo pyrimidine derivatives and composition for preventing or treating cancer comprising the same

The present invention relates to a novel pyrrolo pyrimidine compound represented by chemical formula 1, pharmaceutically acceptable salt or hydrate thereof, a manufacturing method thereof, and a pharmaceutical composition comprising the compound for preventing or treating cancer. In chemical formula 1, R^1, R^2, R^3, R^4, R^5, and X are the same as defined in the specification.COPYRIGHT KIPO 2016

Ethyl cinnamate derivatives as promising high-efficient acaricides against Psoroptes cuniculi: Synthesis, bioactivity and structure-activity relationship

This paper reported the synthesis, structure-activity relationship (SAR) and acaricidal activity in vitro against Psoroptes cuniculi, a mange mite, of 25 ethyl cinnamate derivatives. All target compounds were synthesized and elucidated by means of MS, 1H- and 13C-NMR analysis. The results showed that 24 out of 25 tested compounds at 1.0 mg/mL demonstrated acaricidal activity in varying degrees. Among them, 6, 15, 26, 27 and 30 showed significant activity with median lethal concentration values (LC50) of 89.3, 119.0, 39.2, 29.8 and 41.2 μg/mL, respectively, which were 2.1- to 8.3-fold the activity of ivermectin (LC50=247.4 μg/mL), a standard drug in the treatment of Psoroptes cuniculi. Compared with ivermectin, with a median lethal time value (LT50) of 8.9 h, 27 and 30 showed smaller LTM50 values of 7.9 and 1.3 h, respectively, whereas 6, 15 and 26 showed slightly larger LT50 values of 10.6, 11.0 and 10.4 h at 4.5 μmol/mL. SARs showed that the presence of o-NO2 or m-NO2 on the benzene ring significantly improved the activity, whereas the introduction of a hydroxy, methoxy, acetoxy, methylenedioxy, bromo or chloro group reduced the activity. (E)-Cinnamates were more effective than their (Z)-isomer. Nevertheless, the carbon-carbon double bond in the acrylic ester moiety was proven not to be essential to improve the activity of cinnamic acid esters. Thus, the results strongly indicate that cinnamate derivatives, especially their dihydro derivatives, should be promising candidates or lead compounds for the development of novel acaricides for the effective control of animal or human acariasis.

On the synthesis of protopine alkaloids

(Chemical Equation Presented) For the synthesis of protopine alkaloids, we studied a reaction sequence based on a ring enlargement of indeno[2,1-a][3] benzazepines by a singlet oxygen oxygenation, followed by conversion of an amide carbonyl group of the resultant 10-membered keto-lactam to a methylene group, which is the last step for completion of the synthesis. The key substances, indeno[2,1-a][3]benzazepines, were prepared by Bischler-Napieralski cyclization of alkoxy-substituted 1-(2-bromobenzyl)-3-benzazepin-2-ones. Steric effects of the substituents in this synthesis were examined.