646057-70-7Relevant academic research and scientific papers
Constrained Derivatives of Stylostatin 1. 1. Synthesis and Biological Evaluation as Potential Anticancer Agents
Forns, Pilar,Piró, Jordi,Cuevas, Carmen,García, Mònica,Rubiralta, Mario,Giralt, Ernest,Diez, Anna
, p. 5825 - 5833 (2003)
Hydroxyaminolactams have been used as constrained surrogates of the Ser-Leu dipeptide in the synthesis of analogues of the cycloheptapeptide stylostatin 1 (2). The rate of cyclization through formation of the Ile-Pro amide bond allowed us to prove that th
Asymmetric synthesis of β-pseudopeptides from chiral 3,4-aziridinolactams
Piro, Jordi,Forns, Pilar,Blanchet, Jerome,Bonin, Martine,Micouin, Laurent,Diez, Anna
, p. 995 - 1004 (2002)
The preparation of chiral 3,4-aziridinopiperidine-2-ones 1 and their reactivity with a range of nucleophiles has been studied. In all cases, nucleophilic attack on compounds 1 occurred exclusively at the C(3) centre, leading to the asymmetric synthesis of
