64657-99-4Relevant academic research and scientific papers
Synthesis of some pyridazinylacetic acid derivatives as a novel class of monoamine oxidase-A inhibitors
Khattab, Sherine Nabil,Bekhit, Adnan Ahmed,El-Faham, Ayman,El Massry, Abdel Moneim,Amer, Adel
experimental part, p. 1717 - 1721 (2009/12/01)
A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.
