64663-60-1

Upstream product

• 937716-72-8 (E)-1-phenylethanone O-(3-hydroxyphenyl)oxime 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 24534-42-7 4-methoxy-2-phenylbenzofuran 
• 700-44-7 6-methoxysalicylaldehyde 
• 480-97-7 4-hydroxybenzofuran 
• 108-90-7 chlorobenzene 
• 108-46-3 recorcinol 
• 41046-67-7 2-iodoresorcinol 
• 536-74-3 phenylacetylene 

Downstream Products

• 1361944-56-0 8-phenyl-2H-furo[2,3-h]-1-benzopyran-2-one 
• 1361944-57-1 4-pentyl-8-phenyl-2H-furo[2,3-h]-1-benzopyran-2-one 
• 1361944-58-2 4,8-diphenyl-2H-furo[2,3-h]-1-benzopyran-2-one 
• 1361944-47-9 2-phenylbenzofuran-4-yl but-2-ynoate 
• 1361944-48-0 2-phenylbenzofuran-4-yl oct-2-ynoate 
• 1361944-49-1 2-phenylbenzofuran-4-yl phenylpropiolate 
• 1361944-46-8 2-phenylbenzofuran-4-yl propiolate 
• 1449688-33-8 2-phenylbenzofuran-4-yl 4-methoxybenzoate 
• 1449688-35-0 2-phenylbenzofuran-4-yl 1-naphthoate 
• 1449688-37-2 2-phenylbenzofuran-4-yl 2-ethoxy-1-naphthoate 
• 1449688-38-3 2-phenylbenzofuran-4-yl 4-chlorobenzoate 
• 1449688-04-3 4-(Benzyloxy)-2-phenylbenzofuran 
• 24534-41-6 2-phenylbenzofuran-4-yl benzoate 
• 1449688-40-7 2-phenylbenzofuran-4-yl 4-nitrobenzoate 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agents

Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind to mu

Deconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofuran

An unprecedented deconstructive reorganization strategy for the de novo synthesis of hydroxylated benzofurans from kojic acid- or maltol-derived alkynes is reported. In this reaction, both the benzene and furan rings were simultaneously constructed, whereas the pyrone moiety of the kojic acid or maltol was deconstructed and then reorganized into the benzene ring as a six-carbon component. Through this strategy, at least one free hydroxyl group was introduced into the benzene ring in a substitution-pattern tunable fashion without protection–deprotection and redox adjustment. With this method, a large number of hydroxylated benzofuran derivatives with different substitution-patterns have been prepared efficiently. This methodology has also been shown as the key step in a collective total synthesis of hydroxylated benzofuran-containing natural products (11 examples).

Preparation method of benzofuran compound

The invention discloses a preparation method of a benzofuran compound. The preparation method comprises a step of subjecting a compound with a structure as shown in a formula (I) which is described inthe specification to a reacting in the presence of a ca

General method for functionalized polyaryl synthesis via aryne intermediates

A method for base-promoted arylation of arenes and heterocycles by aryl halides and aryl triflates is described. Additionally, in situ electrophilic trapping of ArLi intermediates generated in the reaction of benzyne with deprotonated arenes or heterocycles has been developed, providing rapid and easy access to a wide range of highly functionalized polyaryls. Base-promoted arylation methodology complements transition-metal-catalyzed direct arylation and allows access to structures that are not easily accessible via other direct arylation methods. The reactions are highly functional-group tolerant, with alkene, ether, dimethylamino, trifluoromethyl, ester, cyano, halide, hydroxyl, and silyl functionalities compatible with reaction conditions.

Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falci

Palladium-catalyzed intramolecular hydroarylation of 4-benzofuranyl alkynoates. Approach to angelicin derivatives

Intramolecular hydroarylation of 4-benzofuranyl alkynoates using Pd(OAc)2 as catalyst took place selectively and efficiently, giving angular furocoumarin derivatives in high yields. The parent angelicin was obtained in 80% yield by this method.

Efficient synthesis of benzofurans utilizing [3,3]-sigmatropic rearrangement triggered by N-trifluoroacetylation of oxime ethers: Short synthesis of natural 2-arylbenzofurans

A new synthetic method for the preparation of benzofurans has been developed. The key step of this method is the [3,3]-sigmatropic rearrangement of N-trifluoroacetyl-ene-hydroxylamines, which was triggered by acylation of oxime ethers. TFAA has been proved to be the best reagent to induce [3,3]-sigmatropic rearrangement for the synthesis of cyclic or acyclic dihydrobenzofurans. On the other hand, the TFAT-DMAP system is found to be the most effective for constructing various benzofurans. Synthetic utility of this reaction is demonstrated by the short synthesis of natural benzofurans without protection of the hydroxy group. The synthesis of Stemofuran A was accomplished via condensation of ketones with aryloxyamine and subsequent reaction with TFAT-DMAP in a four-step synthesis with 72% overall yield. Similarly, Eupomatenoid 6 and Coumestan were synthesized through the reaction of oxime ether with TFAT-DMAP. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.