24534-41-6

Upstream product

• 73374-12-6 C₂₁H₁₅BrO₄ 
• 41046-67-7 2-iodoresorcinol 
• 536-74-3 phenylacetylene 
• 64663-60-1 4-hydroxy-2-phenylbenzofuran 
• 98-88-4 benzoyl chloride 
• 108-46-3 recorcinol 
• 79-03-8 propionyl chloride 

Relevant academic research and scientific papers

Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falci

REDUCTION PAR LES SELS CHROMEUX DE BROMURES BENZYLIQUES ORTHO-O-ACYLES AVEC TRANSPOSITION DU GROUPEMENT ACYLE DE L'ESTER: ACCES AUX ORTHO-HYDROXYBENZYL CETONES NON MASQUEES ET UNE NOUVELLE PREPARATION DE BENZO(B)FURANNES SUBSTITUES EN POSITION-2

The ?-bonded organochromium (III) complexes resulting from the reduction of ortho-O-acyl benzylic bromides 1 with CrCl2 undergo an 1,5-transposition of the ester acyl functional group which allows, through selected experimental conditions either a selective access to the unmasked ortho-hydroxybenzyl ketones 2 or a new preparation of the 2-substituted benzofurans 3.The scope and limitations of the method are presented.

Chromium(II) Salt mediated Reductive Transposition of an Ester Acyl Group in ortho-O-Acyl Benzylic Bromides: a Ready Access to Unmasked ortho-Hydroxybenzyl Ketones and a New Route to Benzofurans

The mono-ο-bonded organochromium(III) complexes (A) derived from (1) rearrange internally into (B) through an acyl ester group transposition, selected experimental conditions allowing either a good access to the unmasked ortho-hydroxybenzyl ketones (2) or a new route to the 2-substituted benzofurans (3).

Process for the synthesis of derivatives of the benzofuran, chromene and isochromene type

The invention relates to a process for the production of therapeutic compounds of the benzofuran, chromene and isochromene type of the general formula; STR1 in which formula, STR2 R1 and R3 =H, lower alkyl, aralkyl or cycloalkyl R2 =H or an organic radical and when D= STR3 R1 and R3 may represent an organic radical. The process comprising the cyclization in the liquid phase and in the presence of a base a compound of the formula; STR4 in which formula; R'=an alkyl, aryl or aralkyl radical and X- =an anion.