64692-99-5Relevant academic research and scientific papers
ANALOGS OF PYRIMIDINE NUCLEOSIDES. 19. SYNTHESIS, ANTINEOPLASTIC ACTIVITY, AND KINETICS OF THE HYDROLYSIS OF 1-(3-PHTHALIDYL)-5-FLUOROURACILS
Zhuk, R. A.,Ludzisha, A. S.,Shpaer, E. G.,Lidak, M. Yu.,Zidermane, A. A.,Meirena, D. V.
, p. 1159 - 1163 (2007/10/02)
1-(3-Phthalidyl)-5-fluorouracils were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with substituted 3-bromophthalides, and the rate constants for hydrolysis at pH 8.0-11.5 were determined.The antineoplastic activity of a number of the compounds was established, and it was assumed that there is a relationship between the biological activity and the rate of hydrolysis.
Biphenylenes. Part 32. A New, General Synthesis of Mono- and Poly-benzodiphenylenes from Substituted benzocyclobutene-1,2-diones and ortho-Bis(cyanomethyl)arenes
Buckland, Paul R.,Hacker, Nigel P.,McOmie, John F. W.
, p. 1443 - 1448 (2007/10/02)
Thirteen examples (including eight novel ring systems) are described of a new, general synthesis of polycyclic biphenylenes from substituted benzocyclobutene-1,2-diones and ortho-bis(cyanomethyl)arenes (benzene, naphthalene, and phenanthrene).Some related condensations are described together with studies on the hydrolysis and decarboxylation of some of the di- and tetra-carbonitriles.
