64700-15-8

Basic information

• Product Name: 7-(CARBOXYMETHOXY)-4-METHYLCOUMARIN
• Synonyms: OTAVA-BB BB0110420050;(4-METHYL-2-OXO-2H-CHROMEN-7-YLOXY)-ACETIC ACID;7-(CARBOXYMETHOXY)-4-METHYLCOUMARIN;AKOS BBS-00007535;AKOS AU36-M187;AURORA 153;4-Methyl-2-oxo-2H-1-benzopyran-7-yloxyacetic acid;Acetic acid, 2-[(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]-
• CAS NO: 64700-15-8
• Molecular Formula: C₁₂H₁₀O₅
• Molecular Weight: 234.2
• Product Categories: Coumarins;Coumarin;Building Blocks;Heterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 64700-15-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 206-208 °C(lit.)
• Boiling Point: 458.5oC at 760 mmHg
• Flash Point: 183oC
• Appearance: /
• Density: 1.375±0.06 g/cm3(Predicted)
• Vapor Pressure: 3.36E-09mmHg at 25°C
• PKA: 3.05±0.10(Predicted)
• CAS DataBase Reference: 7-(CARBOXYMETHOXY)-4-METHYLCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(CARBOXYMETHOXY)-4-METHYLCOUMARIN(64700-15-8)
• EPA Substance Registry System: 7-(CARBOXYMETHOXY)-4-METHYLCOUMARIN(64700-15-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 64700-15-8(Hazardous Substances Data)

Usage

Uses

7-(Carboxymethoxy)-4-methylcoumarin (CMC) was used in the preparation of poly(4-vinyl pyridine)-CMC, photosensitive polymer and 3-chloro-7-[(chlorocarbonyl)methoxy]-4-methylcoumarin.

General Description

Synthesis of a novel fluorescent probe, Tb(III) - (7-carboxymethoxy-4-methylcoumarin) complex, for sensing of DNA has been reported.

InChI:InChI=1/C12H10O5/c1-7-4-12(15)17-10-5-8(2-3-9(7)10)16-6-11(13)14/h2-5H,6H2,1H3,(H,13,14)/p-1

Upstream product

• 1394863-39-8 1-oxo-1-phenylpropan-2-yl 2-(4-methylcoumarin-7-yloxy)acetate 

Downstream Products

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 302937-82-2 butyl 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetate 
• 69560-70-9 7-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy)-4-methyl-2H-chromen-2-one 
• 69321-36-4 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-acetohydrazide 
• 69321-29-5 2-(2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetyl)-N-phenylhydrazine carbothioamide 
• 431040-69-6 2-[N-(4-methyl-2-oxobenzo[b]pyran-7-yloxyacetyl)-N-(2-p-tolylsulfonylaminophenyl)aminomethylene]-2,3-dihydrobenzo[b]thiophen-3-one 
• 431040-67-4 2-[N-(4-methyl-2-oxobenzo[b]pyran-7-yloxyacetyl)-2-methoxyphenylaminomethylene]-2,3-dihydrobenzo[b]thiophen-3-one 
• 89316-64-3 methyl 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetate 
• 91454-65-8 7-<(chlorocarbonyl)methoxy>-4-methylcoumarin 

Relevant articles and documents

Phenacyl ester derivatives bearing heterocycles as models for photocleavable linkers: Synthesis and photolysis studies

The synthesis of several phenacyl ester derivatives linked to oxygen and nitrogen heterocycles, benzoquinolone and (benzo)coumarins, was carried out in an effort to obtain systems that could be applied as photocleavable (bi)functional linkers for solid phase peptide synthesis. The heterocycles were attached to a spacer, with different lengths, followed by coupling to 2-bromo-1-phenylpropan-1-one, acting as a model for the solid support. Photolysis studies of the resulting phenacyl ester derivatives were carried out by irradiation in a photochemical reactor at different wavelengths (300, 350 and 419 nm), in methanol/HEPES buffer solution (80:20).