89316-64-3

Upstream product

• 67-56-1 methanol 
• 64700-15-8 7-(carboxymethoxy)-4-methylcoumarin 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 96-32-2 bromoacetic acid methyl ester 
• 181482-48-4 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetamide 

Downstream Products

• 69321-36-4 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-acetohydrazide 
• 69321-29-5 2-(2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetyl)-N-phenylhydrazine carbothioamide 
• 69560-70-9 7-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy)-4-methyl-2H-chromen-2-one 

Relevant academic research and scientific papers

A self-assembled conjugated micelle with improved sensitivity for monitoring alkaline phosphatase activity

An amphiphilic coumarin derivative which forms a π-extended micelle conformation 1 was designed and developed. The exciton efficiently migrates throughout the coumarin aggregates of 1, showing amplified fluorescence quenching in the presence of Cu2+ ions. The 1-Cu2+ complex displays a highly sensitive response to pyrophosphate (PPi), leading to 80% fluorescence recovery. The activity of alkaline phosphatase (ALP) was monitored by a real-time assay where a solution containing 1, Cu2+, and PPi in aqueous solution exhibits a sensitive turn-off fluorescence response to ALP.

Hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches

New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

Synthesis and Biological Activity of 1-(4-Methyl-2-oxo-2H-benzopyran-7-yloxoacetyl)-4-alkylthiosemicarbazides: 1,3-Thiadiazoles and 1,2,4-Triazoles

A series of 1-(4-methyl-2-oxo-2H-1-benzopyran-7-yloxoacetyl)-4-alkylthiosemicarbazides, S-triazoles and their methyl derivatives has been synthesized by condensation of 4-methyl-2-oxo-2H-1-benzopyran-7-yloxo-acetyl hydrazine with alkyl isothiocyanates.Subsequent ring closure of the substituted thiosemicarbazides yielded the S-triazoles and reaction with methyl iodide gave the corresponding methyl derivatives.The substituted 1,3,4-thiadiazoles have been synthesized by cyclodehydration of the substituted thiosemicarbazides with phosphoric acid.The biological activity of some new compounds is reported. - Key Words: Substituted 1,3,4-Thiadiazoles; 1,2,4-Triazoles; Biological activity.