647016-61-3Relevant academic research and scientific papers
Isothiazole derivatives as GPR120 agonists for the treatment of type II diabetes
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Page/Page column 165; 166, (2015/07/07)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.
ISOTHIAZOLE DERIVATIVES AS GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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Page/Page column 188-189, (2015/11/02)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.
GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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Paragraph 1090, (2014/09/30)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
Regiospecific Suzuki coupling of 3,5-dichloroisothiazole-4-carbonitrile
Christoforou, Irene C.,Koutentis, Panayiotis A.,Rees, Charles W.
, p. 2900 - 2907 (2007/10/03)
3,5-Dichloroisothiazole-4-carbonitrile 1 reacts with aryl- and methylboronic acids to give in high yields the 3-chloro-5-(aryl and methyl)-isothiazole-4-carbonitrile 2 regiospecifically. The reaction was optimized with respect to base, phase transfer agent and palladium catalyst. Suzuki coupling at C-5 was also achieved in high yield using potassium phenyltrifluoroborate. The regiospecificity of either coupling method is maintained with 3,5-dibromoisothiazole-4-carbonitrile 4 to give exclusively 3-bromo-5-phenylisothiazole-4-carbonitrile 5. Suzuki cross-coupling conditions applied to 3-chloro-5-phenylisothiazole-4-carbonitrile 2a gave 3-phenoxy-5-phenylisothiazole-4-carbonitrile 6, which was prepared independently, and not the 3-phenyl derivative. All isothiazole products were fully characterized.
Synthesis and antiviral activity of a new series of 4-isothiazolecarbonitriles
Cutri, Christian C. C.,Garozzo, Adriana,Siracusa, Maria A.,Sarva, Maria C.,Tempera, Gianna,Geremia, Ernesto,Pinizzotto, Maria R.,Guerrera, Francesco
, p. 2271 - 2280 (2007/10/03)
A series of 4-isothiazolecarbonitriles was synthesized and screened for in vitro antiviral activity. The effect of various substituents on the phenyl ring, as well as the substitution of the phenyl for other aromatic and heteroaromatic rings, was examined
