64736-53-4

Basic information

• Product Name: 1H-Imidazole-2-carboxylic acid, 4,5-dichloro-
• Synonyms: 1H-Imidazole-2-carboxylic acid,4,5-dichloro;4,5-dichloroimidazole-2-carboxylic acid
• CAS NO: 64736-53-4
• Molecular Formula: C4H2Cl2N2O2
• Molecular Weight: 180.97700
• Mol File: 64736-53-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 159-160 °C (decomp)
• Boiling Point: 463.0±48.0 °C(Predicted)
• Density: 1.857±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Imidazole-2-carboxylic acid, 4,5-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-2-carboxylic acid, 4,5-dichloro-(64736-53-4)
• EPA Substance Registry System: 1H-Imidazole-2-carboxylic acid, 4,5-dichloro-(64736-53-4)

Safety Data

• Hazardous Substances Data: 64736-53-4(Hazardous Substances Data)

Usage

Preparation

A mixture of 137 g (1 mol) of 4,5-dichloroimidazole, 414 g (3 mol) of K2CO3 and 1,000 ml of carbon dioxide was stirred in an autoclave at 200° C. under autogenous pressure for 10 hours. The solid output was pulverized, suspended in 2 1 of water and brought to pH 3-4 with concentrated hydrochloric acid while being cooled with ice. The resulting precipitate was filtered off and recrystallized from water to give 136 g (75%) of 4,5-dichloroimidazole-2-carboxylic acid; mp. 240° C. (dec.).

Upstream product

• 124-38-9 carbon dioxide 
• 7682-38-4 2,4,5-trichloro-1H-imidazole 
• 16076-27-0 2-bromo-4,5-dichloro-1 H-imidazole 
• 584-08-7 potassium carbonate 
• 15965-30-7 4,5-dichloroimidazole 
• 64738-53-0 2,3,7,8-tetrachloro-5H,10H-diimidazo<1,2-a:1',2'-d>pyrazine-5,10-dione 
• 16042-25-4 1H-imidazole-2-carboxylic acid 

Downstream Products

• 15965-30-7 4,5-dichloroimidazole 

Relevant articles and documents

IMIDAZOLE CARBONYL COMPOUND

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

Katalytische Synthesen funktionalisierter Stickstoffheterocyclen aus Dicyan

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A CONVENIENT SYNTHESIS OF 4(5)-MONO-, 4,5-DI-, AND 2,4,5-TRI-SUBSTITUTED IMIDAZOLES

A procedure is described for the stepwise introduction of substituents (hydrogen included) into the imidazole ring by FGI of the bromine atoms in 1-protected 2,4,5-tribromo-imidazoles in the order 2-5-4 using halogen-metal exchange techniques.