647852-18-4

Upstream product

• 6591-61-3 (S)-Phenylglycine methyl ester 
• 647852-02-6 [(S)-2-Oxo-3-phenyl-3-(trityl-amino)-propyl]-phosphonic acid dimethyl ester 
• 647851-99-8 methyl N-trityl-(S)-phenylglycinate 
• 2935-35-5 (S)-2-phenylglycine 

Downstream Products

• 144541-45-7 methyl (2S,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 
• 146848-91-1 (4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester 
• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 

Relevant academic research and scientific papers

A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

Practical synthetic routes to β-amino-α-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of β-amino-α- keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation.