64788-47-2

Upstream product

• 10487-31-7 1-isopropyl-1H-indole-2,3-dione 
• 91-56-5 indole-2,3-dione 
• 1239867-53-8 2-(2-bromophenyl)-N-isopropylacetamide 
• 18698-97-0 ortho-bromophenylacetic acid 
• 768-52-5 N-Isopropylaniline 
• 161455-97-6 2-bromo-N-isopropyl-N-phenyl-acetamide 

Relevant academic research and scientific papers

Annulation reaction of cyclic pyridinium ylides with: In situ generated azoalkenes for the construction of spirocyclic skeletons

Two new types of cyclic pyridinium ylides were designed and further used in reactions with azoalkenes to access structurally diverse spirocyclic compounds. A range of spiropyrazoline oxindoles could be smoothly obtained in up to 99% yield via a [4 + 1] annulation process with oxindole 3-pyridinium ylides as C1 synthons. Similarly, a series of spiropyrazoline indanones could be prepared with indanone 2-pyridinium ylides as C1 synthons. This work represents the first example of cyclic pyridinium ylides as C1 synthons for the efficient construction of spirocyclic compounds.

Synthesis of Oxindole Derivatives via Intramolecular C–H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst

This work presented the efficient intramolecular aromatic C–H insertion of diazoacetamide. The 1a–1o diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramolecular C–H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min?1 (TOF).

Cyclization and oxidation of o-bromophenylacetamides for the synthesis of oxindoles and isoindigoes

N-substituted oxindoles were obtained through a facile KOH/DMSO promoted intramolecular cyclization of o-bromophenylacetamides in good yields. Furthermore, isoindigo derivatives were readily synthesized through sequential intramolecular cyclization, oxida

A 2 - indolone derivatives and its preparation method

The invention relates to 2-indolone derivatives and a preparation method thereof. The structural formula is disclosed in the specification, wherein R1 is H, 4-Cl or 5-OCH3; and R2 is n-Bu, Cy, Bn, (4-OCH3)-Bn, i-Pr, n-C12H25, (4-Cl)-Bu, (4-Cl)-Bn or (4-OC

Regioselective synthesis of heteroaryl triflones by LDA (lithium diisopropylamide)-mediated anionic thia-Fries rearrangement

Novel heteroaryl triflones including oxindole, pyrazolone, pyridine, and quinoline derivatives have been regioselectively synthesized by LDA-mediated thia-Fries rearrangement for the first time. These reactions are also the first examples of the application of anionic thia-Fries rearrangement in heteroaromatic compounds.

OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein X is C1-4alkyl; and Y is H or F. The compounds of the present invention are useful as antibacterial agents.

Oxazolidinones containing oxindoles as antibacterial agents

The present invention relates to novel oxazolidinones derivatives of oxindoles of formula I, or a pharmaceutically acceptable salt thereof wherein Y1 is —CH— or —CF—; R1 is —C1-4alkyl, optionally substituted with a fluoro atom, or R1 is —C3-5cycloalkyl; and R2 is —H or —CH3. These compounds are useful as antibacterial agents.

Oxindole oxazolidinone as antibacterial agent

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. The compound is useful as antibacterial agents.