64789-03-3

Basic information

• Product Name: 4-Methyl-2-[(4-methylphenyl)sulfonyl]quinoline
• Synonyms: 4-Methyl-2-[(4-methylphenyl)sulfonyl]quinoline
• CAS NO: 64789-03-3
• Molecular Formula: C₁₇H₁₅NO₂S
• Molecular Weight: 297.3715
• Mol File: 64789-03-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 509.9°C at 760 mmHg
• Flash Point: 262.2°C
• Appearance: /
• Density: 1.251g/cm³
• Vapor Pressure: 5.18E-10mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 4-Methyl-2-[(4-methylphenyl)sulfonyl]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-2-[(4-methylphenyl)sulfonyl]quinoline(64789-03-3)
• EPA Substance Registry System: 4-Methyl-2-[(4-methylphenyl)sulfonyl]quinoline(64789-03-3)

Safety Data

• Hazardous Substances Data: 64789-03-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H15NO2S/c1-12-7-9-14(10-8-12)21(19,20)17-11-13(2)15-5-3-4-6-16(15)18-17/h3-11H,1-2H3

Upstream product

• 634-47-9 2-chloro-4-methylquinoline 
• 536-57-2 p-toluene sulfinic acid 
• 4053-40-1 4-methylquinoline 1-oxide 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Relevant articles and documents

Fast regioselective sulfonylation of pyridine/quinoline N-oxides induced by iodine

Fast sulfonylation of pyridine/quinoline N-oxides induced by iodine is demonstrated herein. The regioselective protocol occurs under metal-free conditions in a short reaction time (10 min), exhibiting high efficiency (up to 92% yield) and good compatibili

Visible-light-induced deoxygenative C2-sulfonylation of quinoline: N -oxides with sulfinic acids

The first example of visible-light-induced deoxygenative C2-sulfonylation of quinoline N-oxides with sulfinic acids in the presence of an organic dye as the catalyst was developed. The reaction conditions are eco-friendly and mild, employing ambient air as the sole oxidant and aqueous acetone solution as the solvent. This approach requires only a very low catalyst loading, allowing gram-scale preparation as well as late-stage modification of biologically active compounds bearing quinoline groups.

TsCl-promoted sulfonylation of quinoline N-oxides with sodium sulfinates in water

An eco-friendly protocol for the synthesis of various 2-sulfonyl quinolines/pyridines through sulfonylation of heteroaromatic N-oxides with sodium sulfinates in water at ambient temperature under metal- and oxidant-free conditions has been developed. The mild reaction conditions, high reaction efficiency, operational simplicity, short reaction time and remarkable functional-group compatibility make the developed protocol very attractive for the preparation of 2-sulfonyl N-heteroaromatic compounds.