64798-38-5

Upstream product

• 1989-25-9 4-chlorocumyl alcohol 
• 917-61-3 sodium isocyanate 
• 99-91-2 para-chloroacetophenone 
• 40919-11-7 2-(4-chlorophenyl)-2-methylpropanoyl Chloride 
• 6258-30-6 2-(4-chlorophenyl)-2-methylpropanoic acid 

Downstream Products

• 64797-61-1 1-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-3-propyl-urea 
• 64796-86-7 1-Butyl-3-[1-(4-chloro-phenyl)-1-methyl-ethyl]-1-methyl-urea 
• 64796-96-9 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-methyl-urea 
• 64796-85-6 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-isopropyl-1-methyl-urea 
• 64796-87-8 1-i-Butyl-3-(p-chloro-α,α-dimethylbenzyl)-1-methylurea 
• 64796-88-9 1-n-Butyl-3-(p-chloro-α,α-dimethylbenzyl)-1-ethylurea 
• 64796-84-5 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-methyl-1-propyl-urea 
• 64796-98-1 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-isopropyl-urea 
• 64796-22-1 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-phenyl-1-propyl-urea 
• 64796-97-0 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-propyl-urea 
• 64797-60-0 1-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-3-ethyl-urea 
• 64822-93-1 C₁₉H₂₃ClN₂O₂ 
• 64797-63-3 1-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-3-pentyl-urea 
• 64796-78-7 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1,1-dipropyl-urea 

Relevant academic research and scientific papers

α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3, X4, X5, R5, R6, R7, R8a, R8b, R9, Z1, Z2 and L are as defined in the description.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Synthesis and Herbicidal Activities of 1,2-Benzisoxazole-3-acetamide Derivatives

Many 1,2-benzisoxazole-3-acetamides were synthesized and their herbicidal activities in the paddy field were studied.Of the compounds tested, N-α,α-dimethylbenzyl-2-bromo-(1,2-benzisoxazol-3-yl)acetamide 10a was the most effective.Details of the synthesis and the results of herbicidal evaluations are given.