64798-38-5

Basic information

• Product Name: Benzene, 1-chloro-4-(1-isocyanato-1-methylethyl)-
• CAS NO: 64798-38-5
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.648
• Mol File: 64798-38-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 256.0±23.0 °C(Predicted)
• Density: 1.08±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-chloro-4-(1-isocyanato-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-(1-isocyanato-1-methylethyl)-(64798-38-5)
• EPA Substance Registry System: Benzene, 1-chloro-4-(1-isocyanato-1-methylethyl)-(64798-38-5)

Safety Data

• Hazardous Substances Data: 64798-38-5(Hazardous Substances Data)

Upstream product

• 1989-25-9 4-chlorocumyl alcohol 
• 917-61-3 sodium isocyanate 
• 99-91-2 para-chloroacetophenone 
• 40919-11-7 2-(4-chlorophenyl)-2-methylpropanoyl Chloride 
• 6258-30-6 2-(4-chlorophenyl)-2-methylpropanoic acid 

Downstream Products

• 64796-86-7 1-Butyl-3-[1-(4-chloro-phenyl)-1-methyl-ethyl]-1-methyl-urea 
• 64796-96-9 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-methyl-urea 
• 64796-88-9 1-n-Butyl-3-(p-chloro-α,α-dimethylbenzyl)-1-ethylurea 
• 64796-98-1 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-isopropyl-urea 
• 64796-79-8 1,1-Dibutyl-3-[1-(4-chloro-phenyl)-1-methyl-ethyl]-urea 
• 64797-00-8 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1,1-dicyclohexyl-urea 
• 64795-51-3 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-methyl-1-phenyl-urea 
• 64796-21-0 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-ethyl-1-p-tolyl-urea 
• 64797-61-1 1-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-3-propyl-urea 
• 17797-11-4 1-(4-chlorophenyl)-1-methylethylamine 
• 64822-92-0 1-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-3-o-tolyl-urea 
• 64795-90-0 1-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-3-(2,4-dimethyl-phenyl)-urea 
• 64796-99-2 1-Benzyl-3-[1-(4-chloro-phenyl)-1-methyl-ethyl]-1-methyl-urea 
• 64797-34-8 C₁₆H₂₃ClN₂O₂ 

Relevant articles and documents

α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.