142035-33-4

Basic information

• Product Name: ethyl N-(phenylmethylene)glycinate
• Synonyms: ethyl N-(phenylmethylene)glycinate
• CAS NO: 142035-33-4
• Molecular Weight: 267.327
• Mol File: 142035-33-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl N-(phenylmethylene)glycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-(phenylmethylene)glycinate(142035-33-4)
• EPA Substance Registry System: ethyl N-(phenylmethylene)glycinate(142035-33-4)

Safety Data

• Hazardous Substances Data: 142035-33-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 2835-06-5 phenylglycin 
• 6097-58-1 ethyl 2-phenyl-2-aminoacetate 
• 72651-17-3 phenylglycine ethyl ester hydrochloride 

Downstream Products

• 144073-04-1 (RS)-2-amino-2-phenyl-4-penten-1-ol 
• 847041-34-3 benzyl (3R,4S)-4-[{[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}(methyl)amino]-3-fluoropiperidine-1-carboxylate 
• 686320-24-1 C₁₂H₁₃NO₄ 
• 686320-25-2 C₁₈H₂₃NO₆ 
• 845256-49-7 (2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl chloride 
• 686320-28-5 4-(2,5-difluorophenyl)-2-phenyl-2-[(1,1,2,2-tetramethylpropoxy)methyl]-2,5-dihydro-1H-pyrrole 
• 686320-23-0 4-Allyl-4-phenyl-1,3-oxazolidin-2-one 
• 845256-48-6 (2S)-4-(2,5-difluorophenyl)-2-phenyl-2-[(1,1,2,2-tetramethylpropoxy)methyl]-2,5-dihydro-1H-pyrrole 
• 193421-73-7 α-allylphenylglycine ethyl ester 
• 294882-34-1 2-(N-formyl)-methylamino-2-phenylbutanol 
• 78483-47-3 2-methylamino-2-phenylbutanol 
• 84333-59-5 Nortrimebutine 
• 27856-08-2 ethyl 2-amino-2-phenylbutanoate hydrochloride 
• 6480-87-1 ethyl 2-amino-2-phenylbutanoate 

Relevant articles and documents

Mitotic kinesin inhibitors

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Highly enantioselective synthesis of β-amino alcohols

N,N-Dialkyl-β-amino alcohols derived from α-amino acids can be rearranged enantiospecifically by using TFAA/Et3N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.

Synthesis of methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate

The first synthesis of the methylamino-2-phenyl-2-butyl-3,4,5- trimethoxybenzoate (desmethyltrimebutine) I is described. This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969. It was used for pharmacokinetic and bioequivalence studies.