142035-33-4

Upstream product

• 100-52-7 benzaldehyde 
• 2835-06-5 phenylglycin 
• 64-17-5 ethanol 
• 6097-58-1 ethyl 2-phenyl-2-aminoacetate 
• 72651-17-3 phenylglycine ethyl ester hydrochloride 

Downstream Products

• 193421-73-7 α-allylphenylglycine ethyl ester 
• 144073-04-1 (RS)-2-amino-2-phenyl-4-penten-1-ol 
• 847041-34-3 benzyl (3R,4S)-4-[{[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}(methyl)amino]-3-fluoropiperidine-1-carboxylate 
• 686320-24-1 C₁₂H₁₃NO₄ 
• 686320-25-2 C₁₈H₂₃NO₆ 
• 845256-49-7 (2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl chloride 
• 686320-28-5 4-(2,5-difluorophenyl)-2-phenyl-2-[(1,1,2,2-tetramethylpropoxy)methyl]-2,5-dihydro-1H-pyrrole 
• 686320-23-0 4-Allyl-4-phenyl-1,3-oxazolidin-2-one 
• 845256-48-6 (2S)-4-(2,5-difluorophenyl)-2-phenyl-2-[(1,1,2,2-tetramethylpropoxy)methyl]-2,5-dihydro-1H-pyrrole 
• 294882-34-1 2-(N-formyl)-methylamino-2-phenylbutanol 
• 78483-47-3 2-methylamino-2-phenylbutanol 
• 84333-59-5 Nortrimebutine 
• 27856-08-2 ethyl 2-amino-2-phenylbutanoate hydrochloride 
• 6480-87-1 ethyl 2-amino-2-phenylbutanoate 

Relevant academic research and scientific papers

Mitotic kinesin inhibitors

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

MITOTIC KINESIN INHIBITORS

The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Highly enantioselective synthesis of β-amino alcohols

N,N-Dialkyl-β-amino alcohols derived from α-amino acids can be rearranged enantiospecifically by using TFAA/Et3N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.

Mitotic kinesin inhibitors

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Synthesis of methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate

The first synthesis of the methylamino-2-phenyl-2-butyl-3,4,5- trimethoxybenzoate (desmethyltrimebutine) I is described. This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969. It was used for pharmacokinetic and bioequivalence studies.