58026-12-3

Usage

InChI:InChI=1/C7H10O5/c1-11-6(9)3-5(4-8)7(10)12-2/h4-5H,3H2,1-2H3

Upstream product

• 109-94-4 formic acid ethyl ester 
• 106-65-0 Dimethyl succinate 
• 107-31-3 Methyl formate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 857754-17-7 N-benzyl-N-(2,3-bis-methoxycarbonyl-propenyl)-phenylalanine methyl ester 
• 860426-55-7 {[benzyl-(1-methoxycarbonyl-ethyl)-amino]-methylene}-succinic acid dimethyl ester 
• 5204-91-1 methyl 5-oxotetrahydro-3-furancarboxylate 
• 85301-38-8 isocytosin-5-ylacetic acid 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 20299-15-4 2-thio-5-<(methylcarboxy)methyl>uridine 
• 1613530-52-1 C₁₈H₂₂N₂O₁₀S 
• 29571-40-2 5-methoxycarbonylmethyl-2-thiouracil 
• 29571-39-9 ethyl 2-(4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate 

Relevant academic research and scientific papers

Insecticide dinotefuran intermediate 3 - hydroxy methyl tetrahydrofuran synthetic method

The invention discloses a synthetic method of pesticide dinotefuran intermediate 3-hydroxymethyl tetrahydrofuran, and the synthetic method is as follows: reacting compound succinic acid dialkyl ester with formic acid alkyl ester in the presence of a strong alkali to obtain a compound III, then obtaining a compound II by a reduction reaction, finally, in the presence of an acid catalyst, obtaining a compound shown as formula I by a dehydration cyclization reaction, and R or R ' respectively independently represents C1-5 alkyl. The synthetic method is low in raw material cost, simple in reaction operation, less in pollution, high in yield of each step, 99% in the yield of the reducing step, and suitable for industrial production.

NOVEL QUINOLINECARBOXYLIC ACID DERIVATIVE AND MEDICAMENT CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a compound that inhibits the formation of amyloid fibrils, an amyloid fibrils formation inhibitor containing the compound, and therapeutic or preventive agents for neurodegenerative diseases. SOLUTION: The present invention provides a compound represented by formula (I). [X is -(CH2)n-; n is an integer of 0-3; Y is a single bond or a divalent linking group such as an alkyl group; Ar is a substituted/unsubstituted phenyl group or pyridyl group; R1 is a substituted/unsubstituted alkyl group; Ar and R1, Ar and Y or R1 and Y may form a ring together; R2-R4 independently represent H, a C1-20 alkyl group or the like]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS

The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Alternative nucleic acid molecules and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

Peptide nucleic acids having antibacterial activity

Methods of and compositions for killing or inhibiting the growth of a bacteria are disclosed. The methods comprise the use of peptide nucleic acids that are targeted to mRNA and/or rRNA. In certain embodiments, methods include the use of one or more separate antibiotics.

Peptide nucleic acids having 2,6-diaminopurine nucleobases

A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8alkylamine side chains.

Linked peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

Peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.