64822-81-7

Basic information

• Product Name: 1-iodooct-1-yn-3-ol
• Synonyms: 1-Iodooct-1-yn-3-ol; 1-octyn-3-ol, 1-iodo-
• CAS NO: 64822-81-7
• Molecular Formula: C₈H₁₃IO
• Molecular Weight: 252.0927
• Mol File: 64822-81-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 264.3°C at 760 mmHg
• Flash Point: 113.7°C
• Density: 1.569g/cm³
• Vapor Pressure: 0.00136mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1-iodooct-1-yn-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-iodooct-1-yn-3-ol(64822-81-7)
• EPA Substance Registry System: 1-iodooct-1-yn-3-ol(64822-81-7)

Safety Data

• Hazardous Substances Data: 64822-81-7(Hazardous Substances Data)

Upstream product

• 818-72-4 1-Octyn-3-ol 
• 66-25-1 hexanal 
• 69498-66-4 1-trimethylsilyloct-1-yn-3-ol 

Relevant articles and documents

Unified synthesis of C1-C19 building blocks of halichondrins via selective activation/coupling of polyhalogenated nucleophiles in (Ni)/Cr-Mediated reactions

A unified synthesis of the C1-C19 building blocks 8-10 of halichondrins A-C was developed from the common synthetic intermediates 26a,b. Acetylenic ketones 26a,b were in turn synthesized via selective activation/coupling of polyhalogenated nucleophiles 23

CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS

The present invention provides unified synthesis of the CI -CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hydridized carbon. The provided efficient selective coupling reactions can allow easy access to the CI -CI 9 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.