64837-53-2

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C5H7N3O2S/c1-2-10-4(9)3-7-8-5(6)11-3/h2H2,1H3,(H2,6,8)

Upstream product

• 1117-63-1 ethyl glyoxylate thiosemicarbazone 
• 79-19-6 thiosemicarbazide 
• 4755-77-5 Ethyl oxalyl chloride 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 98022-46-9 amino-[1,3,4]thiadiazole-2-carboxylic acid hydrazide 
• 99845-53-1 (4-hydroxy-phenylazo)-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 1030613-07-0 5-bromo[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 1251526-24-5 C₂₃H₂₈ClN₅O₄S 
• 1239311-04-6 ethyl trans-5-[4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoylamino][1.3.4]thiadiazole-2-carboxylate 
• 56951-58-7 2-amino-5-hydroxymethyl-1,3,4-thiadiazole 
• 64837-49-6 5-chloro-1,3,4-thiadiazole-2-carboxylic acid ethyl ester 
• 63326-73-8 5-Amino-1,3,4-thiadiazol-2-carbonsaeure 
• 1191951-75-3 ethyl 5-(4-decanamidophenylsulfonamido)-1,3,4-thiadiazole-2-carboxylate 
• 1191951-74-2 ethyl 5-(4-acetamidophenylsulfonamido)-1,3,4-thiadiazole-2-carboxylate 
• 1191951-63-9 ethyl 5-(4-dodecylphenylsulfonamido)-1,3,4-thiadiazole-2-carboxylate 
• 88947-29-9 5-amino-[1,3,4]thiadiazole-2-carboxylic acid amide 

Relevant academic research and scientific papers

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides

[Figure not available: see fulltext.] Unusual reaction proceeding via the electrophilic activation of nitroalkanes in the presence of polyphosphoric acid has been discovered. Subsequent nucleophilic attack with semicarbazides or thiosemicarbazides allows

IMIDAZOLE DERIVATIVES AS CYP17 INHIBITORS FOR THE TREATMENT OF CANCER

The present application provides novel imidazole compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP 17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

SUBSTITUTED QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

1,3,4-Thiadiazoles by Reaction of Dithiocarboxylic Esters with Carbonic Hydrazides

1,1-Dithiooxalic esters 1 and heteroaryl dithiocarboxylic esters 2 react with carbonic hydrazides yielding 1,3,4-thiadiazoles.The 1-thiooxamoyl semicarbazides 3 or 1-heteroylthiocarbonyl semicarbazides 4, primarily formed by thioacylation of semicarbazide