64837-53-2

Basic information

• Product Name: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLATE;5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;5-Amino-1,3,4-thiadiazole-2-carboxylic acid ethyl;Ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate ,97%;5-AMino-1,3,4-thiadiazol-2-carboxylic acid ethyl ester;5-aMino-1,3,4-thiadiazole-2-carboxylate;1,3,4-Thiadiazole-2-carboxylicacid, 5-aMino-, ethyl ester
• CAS NO: 64837-53-2
• Molecular Formula: C₅H₇N₃O₂S
• Molecular Weight: 173.19
• Product Categories: Building Blocks
• Mol File: 64837-53-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 197-199°C
• Boiling Point: 317.9 °C at 760 mmHg
• Flash Point: 146.1 °C
• Appearance: /
• Density: 1.419 g/cm³
• Vapor Pressure: 0.000374mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.82±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(64837-53-2)
• EPA Substance Registry System: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(64837-53-2)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 64837-53-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C5H7N3O2S/c1-2-10-4(9)3-7-8-5(6)11-3/h2H2,1H3,(H2,6,8)

Upstream product

• 333-20-0 potassium thioacyanate 
• 79-19-6 thiosemicarbazide 
• 4755-77-5 Ethyl oxalyl chloride 
• 1117-63-1 ethyl glyoxylate thiosemicarbazone 

Downstream Products

• 1191951-75-3 ethyl 5-(4-decanamidophenylsulfonamido)-1,3,4-thiadiazole-2-carboxylate 
• 1191951-74-2 ethyl 5-(4-acetamidophenylsulfonamido)-1,3,4-thiadiazole-2-carboxylate 
• 1191951-63-9 ethyl 5-(4-dodecylphenylsulfonamido)-1,3,4-thiadiazole-2-carboxylate 
• 1030613-07-0 5-bromo[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 88947-29-9 5-amino-[1,3,4]thiadiazole-2-carboxylic acid amide 
• 99845-53-1 (4-hydroxy-phenylazo)-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 98022-46-9 amino-[1,3,4]thiadiazole-2-carboxylic acid hydrazide 
• 64837-49-6 5-chloro-1,3,4-thiadiazole-2-carboxylic acid ethyl ester 
• 56951-58-7 2-amino-5-hydroxymethyl-1,3,4-thiadiazole 
• 63326-73-8 5-Amino-1,3,4-thiadiazol-2-carbonsaeure 
• 1239311-04-6 ethyl trans-5-[4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoylamino][1.3.4]thiadiazole-2-carboxylate 
• 1251526-24-5 C₂₃H₂₈ClN₅O₄S 

Relevant articles and documents

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

IMIDAZOLE DERIVATIVES AS CYP17 INHIBITORS FOR THE TREATMENT OF CANCER

The present application provides novel imidazole compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP 17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

1,3,4-Thiadiazoles by Reaction of Dithiocarboxylic Esters with Carbonic Hydrazides

1,1-Dithiooxalic esters 1 and heteroaryl dithiocarboxylic esters 2 react with carbonic hydrazides yielding 1,3,4-thiadiazoles.The 1-thiooxamoyl semicarbazides 3 or 1-heteroylthiocarbonyl semicarbazides 4, primarily formed by thioacylation of semicarbazide