648424-11-7Relevant academic research and scientific papers
AMINO ALCOHOL COMPOUNDS AND USES THEREOF
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Page/Page column 41-42, (2021/12/31)
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51)
Korosec, Tina,Acimovic, Jure,Seliskar, Matej,Kocjan, Darko,Tacer, Klementina Fon,Rozman, Damjana,Urleb, Uros
, p. 209 - 221 (2008/04/12)
Novel cholesterol biosynthesis inhibitors, a group of pyridylethanol(phenylethyl)amine derivatives, were synthesized. Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14α-demethylase (CYP51). Structu
Synthesis, conformation, and stereodynamics of a salt of 2-{[2-(3,4-dichlorophenyl)-ethyl]propylamino}-1-pyridin-3-ylethanol
Korosec, Tina,Grdadolnik, Joze,Urleb, Uros,Kocjan, Darko,Grdadolnik, Simona Golic
, p. 792 - 795 (2007/10/03)
A novel synthetic route was developed for 2-{[2-(3,4-dichlorophenyl)ethyl] propylamino}-1-pyridin-3-ylethanol (4). A dynamic process due to nitrogen inversion at the central amine nitrogen has been identified by NMR spectroscopy for the dihydrobromide sal
NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page 18-19, (2008/06/13)
The novel derivatives of pyridylethanol (phenylethyl) amines of formula I are described wherein n is an integer from 1 to 4, R1 is a hydrogen atom, hydroxyl group or lower C1-6 alkoxy group R2 is a hydrogen atom or a straight or branched lower C1-6 alkyl group X, is hydrogen, fluorine, chlorine, bromine, hydroxyl group, trifluoromethyl group, 3,4-di-CI,2,4-di-CI or lower C1-6 alkoxy group, the enantiomers, diastereoisomers or racemates thereof or the physiologically acceptable acid addition salts thereof which are ligands of sigma receptors for inhibiting cholesterol biosynthesis and are thus appropriate for the treatment of hypercholesterolemia and hyperlipemia in humans. The greatest lowering of cholesterol was observed by 1-(d-pyridyl)-2-(N-(2-(3,4-dicholorophenyl)ethyl-N-propylamino)ethanol in the form of dihydrobromide salt (signature BK-35. 2HBr).
