648433-09-4Relevant academic research and scientific papers
Synthesis of (+)-(1S,2R) and (-)-(1R,2S)-2-aminocyclobutane-1-carboxylic acids
Gauzy, Christine,Pereira, Elisabeth,Faure, Sophie,Aitken, David J.
, p. 7095 - 7097 (2004)
(+)-(1S,2R) and (-)-(1R,2S)-2-aminocyclobutane-1-carboxylic acids have been prepared in >97% ee and in 33% and 20% overall yields starting from a single, chiral, bicyclic compound perceived as a chiral uracil equivalent. Construction of the cyclobutane ri
Expedient preparation of all isomers of 2-aminocyclobutanecarboxylic acid in enantiomerically pure form
Fernandes, Carlos,Pereira, Elisabeth,Faure, Sophie,Aitken, David J.
supporting information; experimental part, p. 3217 - 3220 (2009/09/26)
A short, convenient, gram scale protocol has been established to allow facile access to all four stereoisomers of 2-ami-nocyclobutanecarboxylic acid, each in enantiomerically pure form (ee >99%). Starting from the readily available cis racemate, the proce
[2+2] Photocycloadditions with chiral uracil derivatives: Access to all four stereoisomers of 2-aminocyclobutanecarboxylic acid
Fernandes, Carlos,Gauzy, Christine,Yang, Yi,Roy, Olivier,Pereira, Elisabeth,Faure, Sophie,Aitken, David J.
, p. 2222 - 2232 (2008/03/28)
Starting from a single, chiral, bicyclic derivative of uracil, all four stereoisomers of 2-aminocyclobutanecarboxylic acid have been prepared in enantiomerically pure form, using a synthetic sequence which begins with a key photochemical [2+2] cycloaddition reaction and includes a practical cis to trans β-amino acid isomerisation procedure. Georg Thieme Verlag Stuttgart.
(+)- and (-)-2-aminocyclobutane-1-carboxylic acids and their incorporation into highly rigid β-peptides: Stereoselective synthesis and a structural study
Izquierdo, Sandra,Rua, Federico,Sbai, Abdelouahid,Parella, Teodor,Alvarez-Larena, Angel,Branchadell, Vicenc,Ortuno, Rosa M.
, p. 7963 - 7971 (2007/10/03)
Several derivatives of (+)- and (-)-2-aminocyclobutane-1-carboxylic acid, 1, have been prepared through enantiodivergent synthetic sequences. The stereoselective synthesis of free amino acid (+)-1 has been achieved, and this product has been fully charact
