6485-55-8

Usage

Uses

Used in Pharmaceutical Industry:
cis-2,6-Dimethylmorpholine is used as a synthetic intermediate for the development of p38α MAP kinase inhibitors. These inhibitors play a crucial role in the treatment of autoimmune diseases by targeting the specific enzyme involved in the immune response, thus helping to regulate the immune system and alleviate the symptoms of autoimmune conditions.
Used in Pharmaceutical Industry (continued):
Additionally, cis-2,6-Dimethylmorpholine is utilized in the synthesis of potent agonists and antagonists of 5-HT4 receptors. These compounds have potential applications in the treatment of various gastrointestinal disorders, as well as in the development of drugs for the central nervous system.
Used in Chemical Synthesis:
Due to its unique chemical properties, cis-2,6-Dimethylmorpholine can also be employed as a solvent or reagent in various chemical synthesis processes. Its clear colorless liquid form and specific reactivity make it suitable for use in the production of a wide range of chemicals and materials.

InChI:InChI=1/C6H13NO/c1-5-3-7-4-6(2)8-5/h5-7H,3-4H2,1-2H3/p+1/t5-,6+

Upstream product

• 110-97-4 diisopropanolamine 
• 141-91-3 2,6-dimethyl morpholine 

Downstream Products

• 64568-28-1 2,6-dimethyl-4-(4-nitro-thiobenzoyl)-morpholine 
• 104587-13-5 10-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-8-phenyl-7H-thieno<2,3-a>quinolizin-7-one 
• 104675-84-5 10-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-4,5-dihydro-8-phenyl-7H-thieno<2,3-a>quinolizin-7-one 
• 104603-97-6 10-chloro-1-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-6,7-dihydro-3-phenyl-4H-benzoquinolizin-4-one 
• 76492-90-5 fenpropimorph 
• 131968-14-4 2,3,3,4,5,5,6-Heptafluoro-2,6-bis-trifluoromethyl-morpholine 
• 66840-50-4 1-ethoxy-perfluoropropane 
• 83935-39-1 bis(perfluoroisopropyl) ether 
• 679839-54-4 2-(2,6-dimethylmorpholin-4-yl)-4-nitrobenzaldehyde 
• 244789-18-2 2-(2,6-dimethylmorpholin-4-yl)ethylamine 
• 141388-89-8 cis-4-[(4,6-dihydro-4-oxo-3-phenylpyrido-[2,1-a]isoindol-1-yl)carbonyl]-2,6-dimethylmorpholine 
• 115225-09-7 4-[ trans-3-(4-trimethylsilylphenyl)cyclobutylmethyl]-cis-2,6-dimethylmorpholine 
• 1020180-13-5 cis-4-(3-bromo-2-methylphenyl)-2,6-dimethylmorpholine 
• 1056877-50-9 C₃₀H₃₅ClN₆O₂ 

Relevant academic research and scientific papers

Preparation method of high-purity cis-2,6-dimethylmorpholine

The invention relates to the technical field of chemical synthesis of medicines, and discloses a preparation method of high-purity cis-2,6-dimethylmorpholine. The method comprises the following steps:subjecting a cis-2,6-dimethylmorpholine-rich mixture of cis-2,6-dimethylmorpholine, trans-2, 6-dimethylmorpholine, cis-2,5-dimethylmorpholine and trans-2,5-dimethylmorpholine to salt formation with micromolecular aliphatic carboxylic acid in an ester solvent, and carrying out recrystallizing to obtain cis-2,6-dimethylmorpholine carboxylate; and dissociating the cis-2,6-dimethylmorpholine carboxylate by using a strong alkaline substance to obtain the high-purity cis-2,6-dimethylmorpholine. According to the method disclosed by the invention, environment-friendly ethyl acetate, isopropyl acetateand butyl acetate are used as reaction solvents and also used as recrystallization solvents, so realization of green production is facilitated which reduction of pollution is realized, impurity content is effectively controlled, finished product purity reaches 99.9% or above, used acids and solvents are friendly to environment, and the method is suitable for industrial production.

Purification method of cis-2, 6-dimethylmorpholine

The invention discloses a purification method of cis-2, 6-dimethylmorpholine, and the method comprises the following steps: providing a mixture of cis-2, 6-dimethylmorpholine, trans-2, 6-dimethylmorpholine, cis-2, 5-dimethylmorpholine and trans-2, 5-dimethylmorpholine, reacting the mixture with carboxylic acid in an ester solvent, and crystallizing to obtain cis-2, 6-dimethylmorpholine carboxylate, wherein the content of the cis-2, 6-dimethylmorpholine in the mixture is greater than or equal to 80 mol%, and hydrolyzing the cis-2, 6-dimethylmorpholine carboxylate with an alkaline substance to obtain the cis-2, 6-dimethylmorpholine. According to the method, the raw material is easy to obtain, the raw material selection range is wider, the process is simple and convenient, the cost is low, the used reagent is environmentally friendly, the purity of the finished product is high, and the use requirements of medicine and other fields can be met.

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.