6485-63-8Relevant articles and documents
Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines
Beisel, Tamara,Diehl, Andreas M.,Manolikakes, Georg
supporting information, p. 4116 - 4119 (2016/08/30)
A general Pd-catalyzed, enantioselective three-component synthesis of α-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of α-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected α-arylglycines.
Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to aromatic α-amino acids: Stable substrates for catalytic arylation reactions
Marques, Carolina S.,Burke, Anthony J.
, p. 10091 - 10097 (2013/11/06)
This paper reports the development of a novel methodology for the catalytic synthesis of aromatic α-amino acids, which involves the addition of aryl-organoboron reagents to α,α-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of α-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest enantioselectivity of 30% ee was obtained using Hayashi's ligand. This method was applied to the synthesis of phenylglycine.
An efficient synthesis of azetidines with (2-bromoethyl)sulfonium triflate
Fritz, Sven P.,Moya, Juan F.,Unthank, Matthew G.,Mcgarrigle, Eoghan M.,Aggarwal, Varinder K.
experimental part, p. 1584 - 1590 (2012/06/29)
Easily accessible arylglycine derivatives were cyclized to azetidines by using commercially available (2-bromoethyl)sulfonium triflate in a simple and mild procedure. The high-yielding reaction has a relatively broad scope and was extended to the synthesi
