Cas 648864-03-3,(E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

648864-03-3

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Basic information

Product Name: (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid
Synonyms: (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid
CAS NO:648864-03-3
Molecular Formula:
Molecular Weight: 513.764
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid(CAS DataBase Reference)
NIST Chemistry Reference: (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid(648864-03-3)
EPA Substance Registry System: (E)-3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid(648864-03-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 648864-03-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 648864-03-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,8,8,6 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 648864-03:
(8*6)+(7*4)+(6*8)+(5*8)+(4*6)+(3*4)+(2*0)+(1*3)=203
203 % 10 = 3
So 648864-03-3 is a valid CAS Registry Number.

648864-03-3Upstream product

648864-03-3Downstream Products

648864-01-1 3-[5-benzo[1,3]dioxol-5-yl-1-(2,5-dichloro-phenyl)-1H-pyrazol-3-yl]-2-(3-chloro-phenyl)-acrylic acid

648864-03-3Relevant academic research and scientific papers

Practical and scalable synthesis of a selective CCK1 receptor antagonist

Mapes, Christopher M.,Mani, Neelakandha S.,Deng, Xiaohu,Pandit, Chennagiri R.,McClure, Kelly J.,Pippel, Marna C. W.,Sehon, Clark A.,Gomez, Laurent,Shinde, Shirin,Breitenbucher, J. Guy,Jones, Todd K.

experimental part, p. 7950 - 7953 (2011/02/22)

We describe a practical and scalable route to compound (Z)-1, a selective CCK1 receptor antagonist. Notable features of this concise route are (1) a regioselective construction of the pyrazole core through the reaction of an aryl hydrazine and

Carboxylation reaction of a highly functionalized vinylic anion: a case of unexpected stability and reactivity

Gomez, Laurent,Wu, Jiejun,Mani, Neelakandha S.,Basu, Sudip,Moravek, Josef,Breitenbucher, J. Guy

supporting information; scheme or table, p. 1110 - 1113 (2010/04/23)

Attempts to prepare JNJ 26273364, a highly functionalized pyrazole-based CCK1 receptor antagonist, using a carboxylation reaction led to a series of unexpected results. This work demonstrated the unique reactivity and stability of the highly fu

Alpha,beta-unsaturated esters and acids by stereoselective dehydration

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Page/Page column 96-97, (2010/02/15)

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making α,β-unsaturated esters, acids and their derivatives.

CCK-1 RECEPTOR MODULATORS

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Page/Page column 215-216, (2010/02/10)

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.

CCK-1 RECEPTOR MODULATORS

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Page 215-216, (2008/06/13)

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.

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