648869-33-4Relevant academic research and scientific papers
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity
Sehon, Clark,McClure, Kelly,Hack, Michael,Morton, Magda,Gomez, Laurent,Li, Lina,Barrett, Terrance D.,Shankley, Nigel,Breitenbucher, J. Guy
, p. 77 - 80 (2007/10/03)
High-throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Here, we disclose the synthesis of combinatorial libraries by solid-phase synthesis on Kenner 'safety catch' resin. Additive QSAR models were used to determine a lack of consistent additive SAR within the matrix.
Alpha,beta-unsaturated esters and acids by stereoselective dehydration
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Page/Page column 75, (2010/02/15)
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making α,β-unsaturated esters, acids and their derivatives.
CCK-1 RECEPTOR MODULATORS
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Page/Page column 172-173, (2010/02/10)
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.
CCK-1 RECEPTOR MODULATORS
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Page 172-173, (2008/06/13)
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
