64891-77-6

Upstream product

• 13291-89-9 [2-13C]-sodium acetate 
• 1563-80-0 (2-¹³C)acetic acid 
• 17830-01-2 <1,1,-13C>acetic anhydride 

Downstream Products

• 134757-64-5 <2-13C>-2-phenoxyacetic acid 
• 20220-62-6 2-⁽¹³⁾C-glycine 
• 106812-97-9 2-cyano-3-(3,4,5-trimethoxyphenyl)<2-13C>propanoic acid 
• 922182-40-9 benzyl bromo(2-¹³C)acetate 
• 741261-83-6 phenylmethoxy-[2-13C]-acetic acid 
• 127477-63-8 C₉⁽¹³⁾CH₁₂O₄ 

Relevant academic research and scientific papers

The preparation of all-trans uniformly 13C-labeled retinal via a modular total organic synthetic strategy. Emerging central contribution of organic synthesis toward the structure and function study with atomic resolution in protein research

Uniformly [13C20]-labeled all-trans-retinal (1) has been prepared via a convergent modular total organic strategy with high isotope incorporation (>99%) and without isotope dilution starting from commercially available 99% enriched

Biosynthesis of Porphyrins and Related Macrocycles. Part 35. Discovery of a Novel Dipyrrolic Cofactor Essential for the Catalytic Action of Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)

The enzyme hydroxymethylbilane synthase constructs the open-chain hydroxymethylbilane by assembly of four porphobilinogen units head-to-tail, the first of these being covalently bound to the enzyme through a group X.The surprising discovery is made that X

Biosynthesis of Porphyrins and Related Macrocycles. Part 16. Proof that the Single Intramolecular Rearrangement leading to Natural Porphyrins (Type-III) occurs at the Tetrapyrrole Level

The unrearranged aminomethylbilane (2) is synthesised by a rational route and is proved to be converted by the enzymes deaminase and cosynthetase, working co-operatively, into uro'gen-III (3).The single rearrangement step established earlier is thus proved to take place at the tetrapyrrole level.Synthesis of singly 13C-labelled bilane (2) followed by its enzymic conversion into uro'gen-III serves to register each of the pyrrole rings of the product relative to the initial bilane.Finally, methods for synthesis of the bilane are developed in two different doubly 13C-labelled forms to allow the following key points to be established largely by 13C n.m.r. spectroscopy: (a) as the bilane system is converted into uro'gen-III, intramolecular rearrangement of the terminal ring D occurs, and (b) the linear tetrapyrrole is converted intact into uro'gen-III.Syntheses of -, and -uroporphyrin octamethyl ester are described together with improved h.p.l.c. conditions for the separation of isomeric coproporphyrin tetramethyl esters.