922182-40-9Relevant academic research and scientific papers
A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry
Stadlmeier, Michael,Bogena, Jana,Wallner, Miriam,Wühr, Martin,Carell, Thomas
, p. 2958 - 2962 (2018)
Modern proteomics requires reagents for exact quantification of peptides in complex mixtures. Peptide labelling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that separate in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical molecular weight but a different mass of the reporter groups, allowing relative quantification of multiple samples in one measurement. Here we report a new isobaric labelling reagent, where the balancer and the reporter are linked by a sulfoxide group, which, based on the sulfoxide pyrolysis, leads to easy and asymmetric cleavage at low fragmentation energy. The fragmentation of our new design is significantly improved, yielding more intense complementary ion signals, allowing complementary ion cluster analysis as well.
SULFOXIDE-BASED REAGENT FOR MASS SPECTROMETRY
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Page/Page column 23; 24, (2019/04/09)
The present invention relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.
Enantioselective syntheses of α-Fmoc-Pbf-[2-13C]-L- arginine and Fmoc-[1,3-13C2]-L-proline and incorporation into the neurotensin receptor 1 ligand, NT8-13
Song, Chuanjun,Tapaneeyakorn, Satita,Murphy, Annabel C.,Butts, Craig,Watts, Anthony,Willis, Christine L.
scheme or table, p. 8980 - 8987 (2010/03/02)
(Chemical Equation Presented) Enantioselective syntheses of selectively labeled, orthogonally protected [2-13C]-L-arginine and [1,3- 13C2]-L-proline are described from the commercially available precursors [2-13C]bromoacetic acid and potassium [ 13C]cyanide. Interestingly the enhanced signal assigned to C-2 in the 13C NMR spectrum of α-Fmoc-Pbf-[2-13C]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-13C]-Arg9 and [1,3-13C2]-Pro10 labeled ligand (NT8-13) by manual Fmoc-SPSS.
Synthesis of selectively 13C-labelled bilin compounds
Makhynya, Yevgen,Hussain, Zakir,Bauschlicher, Tanja,Schwinte, Pascale,Siebert, Friedrich,Gaertner, Wolfgang
, p. 1287 - 1293 (2008/09/18)
A series of open-chain tetrapyrroles, each carrying one or more 13C-labels in its three ring-bridging methine groups, were synthesized. These compounds - [5-, [10-, and [15-13C]- phycocyanobilins (PCB), [10-13C]-phytochrom
