648936-11-2

Upstream product

• 648936-10-1 (3aS,6aR)-(3,3-dimethoxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)phenylmethanone 
• 134037-95-9 Cbz-L-Leucine fluoride 
• 178206-96-7 (R)-2-methoxycarbonylmethyl-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 648936-09-8 (3aR,6aS)-4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 648936-07-6 (3aR,6S,6aS)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 648936-08-7 (3aR,6aS)-4-benzoyl-6-oxo-hexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 648930-90-9 (-)-(3S,3aS,6aR)-3-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 648930-86-3 (R)-2-(2-azidoethyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 648936-21-4 (R)-2-(2-aminoethyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 648930-83-0 (S)-2-(2-diazoacetyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 51154-06-4 (S)-2,5-dihydropyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 
• 93-97-0 benzoic acid anhydride 
• 2018-66-8 Z-Leu-OH 
• 648930-87-4 (-)-(R)-2-(2-benzyloxycarbonylaminoethyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 648936-13-4 (-)-(3aR,6aS)-N-[(1S)-1-(4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrole-1-carbonyl)-3-methylbutyl]-4-tert-butylbenzamide 
• 648936-12-3 (2S,3aR,6aS)-2-amino-1-(4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)-4-methylpentan-1-one 

Relevant academic research and scientific papers

Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

A stereoselective synthesis of functionalised cis-hexahydropyrrolo[3,2-b] pyrrol-3-ones has been developed through Fmoc and Cbz-protected intermediates 5 and 6. Building blocks 5 and 6 were prepared via the intramolecular cyclisation of anti-epoxide 17. T

BIOLOGICALLY ACTIVE COMPOUNDS

Compounds of general formula (I) wherein: Z = CR3R4, where R3 and R4 are independently chosen from CO-7-alkyl P1 = CR5R6, P2 = O, CR7R8/sup