648930-87-4

Upstream product

• 178206-96-7 (R)-2-methoxycarbonylmethyl-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 51154-06-4 (S)-2,5-dihydropyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 
• 847183-09-9 (R)-2-(2-methanesulfonylethyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 648930-86-3 (R)-2-(2-azidoethyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 648930-83-0 (S)-2-(2-diazoacetyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 648930-84-1 (-)-(R)-2-(2-hydroxyethyl)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 648930-88-5 (R)-2-(2-benzyloxycarbonylaminoethyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester 
• 648936-13-4 (-)-(3aR,6aS)-N-[(1S)-1-(4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrole-1-carbonyl)-3-methylbutyl]-4-tert-butylbenzamide 
• 648936-18-9 (-)-(3aR,6aS)-N-[(1S)-1-((6S)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1-carbonyl)-3-methylbutyl]-4-tert-butylbenzamide 
• 648936-11-2 (-)-(3aR,6aS)-[(1S)-1-(4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrole-1-carbonyl)-3-methylbutyl]carbamic acid benzyl ester 
• 648936-16-7 (-)-(3aR,6aS)-[(1S)-1-((6S)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1-carbonyl)-3-methylbutyl]carbamic acid benzyl ester 
• 648936-12-3 (2S,3aR,6aS)-2-amino-1-(4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)-4-methylpentan-1-one 
• 648936-09-8 (3aR,6aS)-4-benzoyl-6,6-dimethoxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 648936-07-6 (3aR,6S,6aS)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 648936-17-8 (2S,3aR,6aS)-2-amino-1-((6S)-4-benzoyl-6-hydroxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)-4-methylpentan-1-one 
• 648936-08-7 (3aR,6aS)-4-benzoyl-6-oxo-hexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 648930-90-9 (-)-(3S,3aS,6aR)-3-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 648936-10-1 (3aS,6aR)-(3,3-dimethoxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)phenylmethanone 
• 648936-15-6 (3S,3aS,6aR)-(3-hydroxyhexahydropyrrolo[3,2-b]pyrrol-1-yl)phenylmethanone 

Relevant academic research and scientific papers

Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

A stereoselective synthesis of functionalised cis-hexahydropyrrolo[3,2-b] pyrrol-3-ones has been developed through Fmoc and Cbz-protected intermediates 5 and 6. Building blocks 5 and 6 were prepared via the intramolecular cyclisation of anti-epoxide 17. T