6490-20-6

Usage

Uses

Used in Pharmaceutical Industry:
Levocarnitine iMpurity is used as a bactericide for preventing and treating bacterial infections. It is derived from L-Carnitine, which is known for its role in energy metabolism and has been found to possess antimicrobial properties.
Used in Nutritional Supplements:
Levocarnitine iMpurity is used as a nutritional supplement to prevent and treat a lack of carnitine. Carnitine deficiency can lead to various health issues, including muscle weakness, fatigue, and cardiovascular problems. Supplementing with Levocarnitine iMpurity can help maintain optimal carnitine levels in the body and support overall health and well-being.
Used in Sports Nutrition:
Levocarnitine iMpurity is used as a sports nutrition supplement to enhance athletic performance and support muscle recovery. Its role in energy metabolism and fatty acid oxidation makes it a popular choice among athletes and fitness enthusiasts looking to improve their endurance and reduce muscle fatigue during exercise.
Used in Weight Management:
Levocarnitine iMpurity is used as a weight management aid to support fat loss and maintain a healthy body weight. By promoting the oxidation of fatty acids, it can help increase the body's energy expenditure and support weight loss efforts.
Used in Cardiovascular Health:
Levocarnitine iMpurity is used to support cardiovascular health by maintaining healthy cholesterol levels and improving blood flow. Its role in energy metabolism and fatty acid oxidation can help reduce the risk of cardiovascular diseases and promote overall heart health.

Upstream product

• 1116-95-6 (D)-(+)-carnitinenitrile chloride 
• 18933-33-0 (R,S)-carnitinenitrile chloride 
• 226213-72-5 (R)-4-chloro-3-hydroxybutanamide 
• 75-50-3 trimethylamine 
• 2788-28-5 (2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride 
• 5261-99-4 (+/-)-carnitinamide chloride 

Downstream Products

• 541-15-1 L-carnitine 
• 161886-59-5 (S)-carnitine mesylate isobutyl ester mesylate 
• 161886-60-8 (S)-carnitine mesylate mesylate 
• 406-76-8 (S)-carnitin 

Relevant academic research and scientific papers

PROCESS FOR PRODUCTION OF BETAINE

According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield. The present invention also relates to a process for preparing a betaine represented by formula (1) below, comprising a step of quaternary aminating an amide represented by formula (2) below: wherein A1, A2 and A3 individually represent a C1-C20 hydrocarbon group which may have a substituent(s); and X1 is a halogen atom.

Entrainment resolution of carnitinamide chloride

The ready availability of (R)-carnitinamide, an immediate synthetic precursor of (R)-carnitine, is an ambitious goal and resolutions, due to the very low cost of racemic carnitinamide, can be the most convenient stereotechnology to reach it. We have efficiently resolved carnitinamide chloride by preferential crystallization from methanol according to simple entrainment procedure. The previous transformation of the chloride into other salts or the use of specific solvent systems was not required for successful resolution, as in the case of the reported entrainment of carnitinamide precursor, carnitine nitrile.

Enantiomeric resolution of a carnitinamide salt by preferential crystallization

A process for the resolution of (D,L)-carnitinamide (D,L-I) chloride in its enantiomers (D-I) and (L-I), characterized in that a supersaturated solution or suspension of (D,L-I) in a suitable solvent or mixture of solvents, optionally added with a surfactant, is used. A series of alternate preferential crystallizations is carried out after adding minimum amount of seeds of one of the two enantiomers, (D-I) or (L-I), that is to be precipitated, and subsequently restoring the supersaturation conditions by adding an appropriate amount of (D,L-I) racemate.