64910-46-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-AMINO-4-(METHYLAMINO)BENZONITRILE is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Organic Chemistry Research:
3-AMINO-4-(METHYLAMINO)BENZONITRILE serves as a valuable research tool in organic chemistry, aiding in the exploration of new chemical reactions and the synthesis of complex organic molecules.
Used as a Fluorescent Probe in Biological Studies:
Leveraging its fluorescent properties, 3-AMINO-4-(METHYLAMINO)BENZONITRILE is employed as a fluorescent probe in biological research, facilitating the study of biological processes and interactions at the molecular level.
Safety Consideration:
3-AMINO-4-(METHYLAMINO)BENZONITRILE is classified as a hazardous substance, necessitating careful handling and adherence to safety protocols during its use in laboratories and industrial settings.

InChI:InChI=1/C8H9N3/c1-11-8-3-2-6(5-9)4-7(8)10/h2-4,11H,10H2,1H3

Upstream product

• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 1009-35-4 4-fluoro-3-nitrobenzonitrile 
• 64910-45-8 4-(methylamino)-3-nitrobenzonitrile 

Downstream Products

• 496937-84-9 2-(4-fluorophenyl)-1-methyl-1H-benzimidazole-5-carbaldehyde 
• 357156-62-8 1-methyl-2-(4-phenoxy-phenyl)-1H-benzoimidazole-5-carbonitrile 
• 53484-13-2 1-methyl-1H-benzo[d]imidazole-5-carbonitrile 
• 1191924-17-0 C₂₂H₁₆Cl₂N₆ 

Relevant academic research and scientific papers

Benzimidazole derivative as well as preparation method and application thereof

The invention discloses a benzimidazole derivative with a structural formula of a general formula A-1, wherein the definition of each substituent group is shown in the specification. The invention also discloses a preparation method and application of the

Small Sequence-Sensitive Compounds for Specific Recognition of the G?C Base Pair in DNA Minor Groove

A series of small diamidines with thiophene and modified N-alkylbenzimidazole σ-hole module represent specific binding to single G?C base pair (bp) DNA sequence. The variation of N-alkyl or aromatic rings were sensitive to microstructures of the DNA minor

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation

Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of N-substituents and with both electron-rich and -poor functionality displayed at different sites of the arene. Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl methacrylate. The method was also shown to be applicable to the C2-selective branched alkylation of azabenzimidazoles.

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI

A series of novel benzimidazole diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a–c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines (15a–c). The n

2-(4-ARYL-1H-IMIDAZOL-1-YL)ANILINE COMPOUNDS

The present invention provides compounds that are useful as vaccine adjuvants and/or antitumor agents and methods for producing and using the same. In one particular aspect of the invention, compounds of the invention are of the formula (I) where R1, R2, R3 and Ar1 are those defined herein.

Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof

Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.

BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.

Efficient solution phase synthesis of 2-(N-acyl)-aminobenzimidazoles

An efficient solution phase protocol for the synthesis of 2-(N-acyl)-aminobenzimidazoles is reported. The 2-(N-acyl)-aminobenzimidazole ring system was assembled using SNAr reactions, nitro group reduction, acylthiourea formation and cyclization with EDC. The acyl protected 2-aminobenzimidazole derivatives were obtained in high yield and purity without purification of intermediates or final products. This reaction sequence eliminates the use of highly toxic cyanogen bromide, a reagent commonly used to prepare the 2-aminobenzimidazole ring system.

Amidino benzimidazole inhibitors of bacterial two-component systems

Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two-component system (TCS). Many of these inhibitors exhibit good in vitro antibacterial activity against a variety of susceptible and resistant Gram-positive organisms.