53484-13-2

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-5-carbonitrile,1-methyl-(9CI) is used as a potential pharmaceutical agent for its possible anti-cancer properties. Benzimidazole derivatives have been found to exhibit various biological activities, including anti-cancer effects, making 1H-Benzimidazole-5-carbonitrile,1-methyl-(9CI) a candidate for further research and development in cancer treatment.
1H-Benzimidazole-5-carbonitrile,1-methyl-(9CI) is also used as a potential pharmaceutical agent for its possible anti-inflammatory and anti-fungal properties. 1H-Benzimidazole-5-carbonitrile,1-methyl-(9CI)'s benzimidazole structure, which is known for these biological activities, suggests that it could be utilized in the development of new drugs targeting inflammation and fungal infections.
Further research and testing are required to determine the specific uses and potential benefits of 1H-Benzimidazole-5-carbonitrile,1-methyl-(9CI) in various industries, including its efficacy, safety, and optimal application methods.

Upstream product

• 67-56-1 methanol 
• 64910-46-9 3-amino-4-(methylamino)benzonitrile 
• 64910-45-8 4-(methylamino)-3-nitrobenzonitrile 
• 939-80-0 4-chloro-3-nitrobenzonitrile 

Relevant academic research and scientific papers

Using Methanol as a Formaldehyde Surrogate for Sustainable Synthesis of N-Heterocycles via Manganese-Catalyzed Dehydrogenative Cyclization

The development of an efficient and sustainable synthetic route for formaldehyde production from renewable feedstock, especially in combination with a subsequent transformation to straightforwardly construct valuable chemicals, is highly desirable. Herein, we report a novel manganese-catalyzed dehydrogenative cyclization of methanol as a formaldehyde surrogate with a variety of dinucleophiles for facile synthesis of N-heterocycles. The in situ generated formaldehyde via catalytic methanol dehydrogenation can be selectively trapped by diverse dinucleophiles to avoid several possible side reactions. The utility of this transformation is further highlighted by its successful application to the synthesis of 13C-labeled N-heterocycles using 13CH3OH as a readily accessible 13C-isotope reagent.

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation

Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of N-substituents and with both electron-rich and -poor functionality displayed at different sites of the arene. Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl methacrylate. The method was also shown to be applicable to the C2-selective branched alkylation of azabenzimidazoles.

2-(4-ARYL-1H-IMIDAZOL-1-YL)ANILINE COMPOUNDS

The present invention provides compounds that are useful as vaccine adjuvants and/or antitumor agents and methods for producing and using the same. In one particular aspect of the invention, compounds of the invention are of the formula (I) where R1, R2, R3 and Ar1 are those defined herein.