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4-Methylamino-3-nitro-benzonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

64910-45-8

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64910-45-8 Usage

Uses

4-(Methylamino)-3-nitrobenzonitrile

Check Digit Verification of cas no

The CAS Registry Mumber 64910-45-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,9,1 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 64910-45:
(7*6)+(6*4)+(5*9)+(4*1)+(3*0)+(2*4)+(1*5)=128
128 % 10 = 8
So 64910-45-8 is a valid CAS Registry Number.

64910-45-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(Methylamino)-3-nitrobenzonitrile

1.2 Other means of identification

Product number -
Other names 4-Methylamino-3-nitro-benzonitril

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64910-45-8 SDS

64910-45-8Relevant articles and documents

Small Sequence-Sensitive Compounds for Specific Recognition of the G?C Base Pair in DNA Minor Groove

Farahat, Abdelbasset A.,Guo, Pu,Shoeib, Hadir,Paul, Ananya,Boykin, David W.,Wilson, W. David

, p. 4539 - 4551 (2020/03/25)

A series of small diamidines with thiophene and modified N-alkylbenzimidazole σ-hole module represent specific binding to single G?C base pair (bp) DNA sequence. The variation of N-alkyl or aromatic rings were sensitive to microstructures of the DNA minor

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation

Tran, Ga?l,Confair, Danielle,Hesp, Kevin D.,Mascitti, Vincent,Ellman, Jonathan A.

, p. 9243 - 9252 (2017/09/11)

Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of N-substituents and with both electron-rich and -poor functionality displayed at different sites of the arene. Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl methacrylate. The method was also shown to be applicable to the C2-selective branched alkylation of azabenzimidazoles.

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI

Farahat, Abdelbasset A.,Bennett-Vaughn, Cheree,Mineva, Ekaterina M.,Kumar, Arvind,Wenzler, Tanja,Brun, Reto,Liu, Yang,Wilson, W. David,Boykin, David W.

, p. 5907 - 5910 (2016/12/03)

A series of novel benzimidazole diamidines were prepared from the corresponding dicyano analogues either by applying Pinner methodology (5a–c, 10 and 13a) or by making amidoximes intermediates that were reduced to the corresponding amidines (15a–c). The n

2-(4-ARYL-1H-IMIDAZOL-1-YL)ANILINE COMPOUNDS

-

Paragraph 0112, (2015/11/27)

The present invention provides compounds that are useful as vaccine adjuvants and/or antitumor agents and methods for producing and using the same. In one particular aspect of the invention, compounds of the invention are of the formula (I) where R1, R2, R3 and Ar1 are those defined herein.

Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof

-

Page/Page column 145, (2011/09/14)

Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.

BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR

-

Page/Page column 59, (2010/11/30)

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS

-

, (2008/06/13)

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.

Efficient solution phase synthesis of 2-(N-acyl)-aminobenzimidazoles

Seth, Punit P.,Robinson, Dale E.,Jefferson, Elizabeth A.,Swayze, Eric E.

, p. 7303 - 7306 (2007/10/03)

An efficient solution phase protocol for the synthesis of 2-(N-acyl)-aminobenzimidazoles is reported. The 2-(N-acyl)-aminobenzimidazole ring system was assembled using SNAr reactions, nitro group reduction, acylthiourea formation and cyclization with EDC. The acyl protected 2-aminobenzimidazole derivatives were obtained in high yield and purity without purification of intermediates or final products. This reaction sequence eliminates the use of highly toxic cyanogen bromide, a reagent commonly used to prepare the 2-aminobenzimidazole ring system.

Amidino benzimidazole inhibitors of bacterial two-component systems

Weidner-Wells, Michele A.,Ohemeng, Kwasi A.,Nguyen, Van N.,Fraga-Spano, Stephanie,Macielag, Mark J.,Werblood, Harvey M.,Foleno, Barbara D.,Webb, Glenda C.,Barrett, John F.,Hlasta, Dennis J.

, p. 1545 - 1548 (2007/10/03)

Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two-component system (TCS). Many of these inhibitors exhibit good in vitro antibacterial activity against a variety of susceptible and resistant Gram-positive organisms.

Selective one-pot N-monomethylation of 2-nitroanilines under PTC conditions

Voskresensky,Makosza

, p. 3523 - 3526 (2007/10/03)

Direct PTC methylation of 2-nitroanilines with dimethyl sulfate gave selectively N-monomethylated products. A variety of N-methyl-2-nitroanilines were prepared in this way.

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